Natural killer (NK) cells are important effectors of innate immunity playing a key role in the
eradication and clearance of viral infections. Over the recent years, several studies have …

Natural killer (NK) cells play a critical role in viral immunity. In the setting of HIV infection,
epidemiologic and functional evidence support a role for NK cells in both protection from …

Background Combination antiretroviral therapy (cART) has dramatically extended the life
expectancy of people living with HIV-1 and improved their quality of life. There is …

The conserved internal influenza proteins nucleoprotein (NP) and matrix 1 (M1) are well
characterised for T cell immunity, but whether they also elicit functional antibodies capable …

Immune exhaustion is an important feature of chronic infections, such as HIV, and a barrier
to effective immunity against cancer. This dysfunction is in part controlled by inhibitory …

Human immunodeficiency virus type 1 (HIV-1) infection causes a progressive depletion of
CD4+ T cells. Despite its importance for HIV-1 pathogenesis, the precise mechanisms …

Anti-HIV-1 broadly neutralizing antibodies (BnAbs) exhibit an impressive capacity to protect
against chimeric SIV-HIV (SHIV) challenges in macaques and potently reduce viremia in …

Abstract Background Tuberculosis (TB) and AIDS are the leading causes of infectious
disease death worldwide. In some TB-HIV co-infected individuals treated for both diseases …

BACKGROUND. Both seasonal and novel avian influenza viruses can result in severe
infections requiring hospitalization. Anti-influenza antibodies (Abs) with Fc-mediated effector …

Broadly neutralizing antibodies (BnAbs) protect macaques from cell-free simian/human
immunodeficiency virus (SHIV) challenge, but their efficacy against cell-associated SHIV is …