Adipose tissue at single-cell resolution

B Maniyadath, Q Zhang, RK Gupta, S Mandrup - Cell metabolism, 2023 - cell.com
Adipose tissue exhibits remarkable plasticity with capacity to change in size and cellular
composition under physiological and pathophysiological conditions. The emergence of …

Mesenchymal stromal cells as conductors of adipose tissue remodeling

J Cannavino, RK Gupta - Genes & Development, 2023 - genesdev.cshlp.org
Adipose tissue exhibits a remarkable capacity to expand, contract, and remodel in response
to changes in physiological and environmental conditions. Here, we describe recent …

Regulatory T cells shield muscle mitochondria from interferon-γ–mediated damage to promote the beneficial effects of exercise

PK Langston, Y Sun, BA Ryback, AL Mueller… - Science …, 2023 - science.org
Exercise enhances physical performance and reduces the risk of many disorders such as
cardiovascular disease, type 2 diabetes, dementia, and cancer. Exercise characteristically …

Organism-wide, cell-type-specific secretome mapping of exercise training in mice

W Wei, NM Riley, X Lyu, X Shen, J Guo, SH Raun… - Cell Metabolism, 2023 - cell.com
There is a significant interest in identifying blood-borne factors that mediate tissue crosstalk
and function as molecular effectors of physical activity. Although past studies have focused …

Molecular control of endurance training adaptation in male mouse skeletal muscle

R Furrer, B Heim, S Schmid, S Dilbaz, V Adak… - Nature …, 2023 - nature.com
Skeletal muscle has an enormous plastic potential to adapt to various external and internal
perturbations. Although morphological changes in endurance-trained muscles are well …

[HTML][HTML] Plasma proteomic changes in response to exercise training are associated with cardiorespiratory fitness adaptations

JM Robbins, P Rao, S Deng, MJ Keyes, UA Tahir… - JCI insight, 2023 - ncbi.nlm.nih.gov
Regular exercise leads to widespread salutary effects, and there is increasing recognition
that exercise-stimulated circulating proteins can impart health benefits. Despite this, limited …

Exercise reprograms the inflammatory landscape of multiple stem cell compartments during mammalian aging

L Liu, S Kim, MT Buckley, JM Reyes, J Kang, L Tian… - Cell stem cell, 2023 - cell.com
Exercise has the ability to rejuvenate stem cells and improve tissue regeneration in aging
animals. However, the cellular and molecular changes elicited by exercise have not been …

Adipocyte p53 coordinates the response to intermittent fasting by regulating adipose tissue immune cell landscape

I Reinisch, H Michenthaler, A Sulaj… - Nature …, 2024 - nature.com
In obesity, sustained adipose tissue (AT) inflammation constitutes a cellular memory that
limits the effectiveness of weight loss interventions. Yet, the impact of fasting regimens on …

[HTML][HTML] Exercise training remodels inguinal white adipose tissue through adaptations in innervation, vascularization, and the extracellular matrix

P Nigro, M Vamvini, J Yang, T Caputo, LL Ho… - Cell reports, 2023 - cell.com
Inguinal white adipose tissue (iWAT) is essential for the beneficial effects of exercise training
on metabolic health. The underlying mechanisms for these effects are not fully understood …

Mesenchymal stem cells and their exocytotic vesicles

H Cai, H Guo - International Journal of Molecular Sciences, 2023 - mdpi.com
Mesenchymal stem cells (MSCs), as a kind of pluripotent stem cells, have attracted much
attention in orthopedic diseases, geriatric diseases, metabolic diseases, and sports …