BACKGROUND Modern reproductive behavior in most developed countries is characterized
by delayed parenthood. Older gametes are generally less fertile, accumulating and …

BACKGROUND Although spontaneous miscarriage is the most common complication of
human pregnancy, potential contributing factors are not fully understood. Advanced …

Male infertility is an increasing and serious medical concern, though the mechanism
remains poorly understood. Impaired male reproductive function affects approximately half …

In modern post-transition societies, we are reproducing later and living longer. While the
impact of age on female reproductive function has been well studied, much less is known …

Clinical infertility is the inability of a couple to conceive after 12 months of trying. Male factors
are estimated to contribute to 30–50% of cases of infertility. Infertility or reduced fertility can …

In 1959, 63 years after the death of John Langdon Down, Jérôme Lejeune discovered
trisomy 21 as the genetic reason for Down syndrome. Screening for Down syndrome has …

Transgender men are assigned female at birth, but self-identify as male. Although some
transgender men undergo gender-affirming hormonal treatment and/or surgery that preclude …

The idea that there is an impenetrable barrier that separates the germline and soma has
shaped much thinking in evolutionary biology and in many other disciplines. However …

With the delay of parenthood becoming more common, the age at which men father children
is on the rise. While the effects of advanced maternal age have been well documented, only …

This review focuses on recent findings in the preimplantation genetic testing (PGT) of
embryos. Different preimplantation genetic tests are presented along with different genetic …