[PDF][PDF] Geroscience and pathology: a new frontier in understanding age-related diseases

M Fekete, D Major, A Feher… - Pathology and …, 2024 - por-journal.com
Geroscience, an emerging discipline at the intersection of aging and disease, seeks to
understand the relationship between the aging process and pathogenesis of age-related …

Distinct tau neuropathology and cellular profiles of an APOE3 Christchurch homozygote protected against autosomal dominant Alzheimer's dementia

D Sepulveda-Falla, JS Sanchez, MC Almeida… - Acta …, 2022 - Springer
We describe in vivo follow-up PET imaging and postmortem findings from an autosomal
dominant Alzheimer's disease (ADAD) PSEN1 E280A carrier who was also homozygous for …

Bioinformatic analysis of the SPs and NFTs proteomes unravel putative biomarker candidates for Alzheimer's disease

MJC Ferreira, T Soares Martins, SR Alves… - …, 2023 - Wiley Online Library
Aging is the main risk factor for the appearance of age‐related neurodegenerative diseases,
including Alzheimer's disease (AD). AD is the most common form of dementia, characterized …

Human amygdala involvement in Alzheimer's disease revealed by stereological and dia‐PASEF analysis

M Gonzalez‐Rodriguez, S Villar‐Conde… - Brain …, 2023 - Wiley Online Library
Alzheimer's disease (AD) is characterized by the accumulation of pathological amyloid‐β
(Aβ) and Tau proteins. According to the prion‐like hypothesis, both proteins can seed and …

Domino-like effect of C112R mutation on ApoE4 aggregation and its reduction by Alzheimer's Disease drug candidate

M Nemergut, SM Marques, L Uhrik, T Vanova… - Molecular …, 2023 - Springer
Abstract Background Apolipoprotein E (ApoE) ε4 genotype is the most prevalent risk factor
for late-onset Alzheimer's Disease (AD). Although ApoE4 differs from its non-pathological …

[HTML][HTML] The molecular mechanisms of steroid hormone effects on cognitive function

HD Nguyen, GH Vu, WK Kim - Archives of Gerontology and Geriatrics, 2025 - Elsevier
Objective There is a lack of information on the molecular mechanisms by which steroid
hormones (testosterone, estrogen, and progesterone) regulate cognitive impairment. Thus …

[HTML][HTML] 元宇宙在老年人群认知衰退干预中的应用场景研究

德富周, 益金, 瑛陈 - Sheng Wu Yi Xue Gong Cheng Xue Za Zhi …, 2023 - ncbi.nlm.nih.gov
我国将迎来老龄化高峰, 老龄群体对智慧型医疗保健的服务需求骤增。 元宇宙作为新型互联网
社会交流空间, 显示出无限应用潜力。 本文聚焦医学元宇宙在老年人群认知衰退干预中的应用 …

Alterations in Sleep, Neuronal Activity, and Metabolism Caused by Alzheimer's Disease-Related Tau Pathology

RE Irmen - 2023 - search.proquest.com
Alzheimer's disease (AD) is a neurodegenerative disease that is growing in prevalence with
an aging population. Along with cognitive impairments, AD patients experience a multitude …

UNRAVELING THE CONSEQUENCE OF ADULT ONSET SULFATIDE DEPLETION: ITS IMPLICATIONS IN MYELIN AND AXONAL HEATH IN THE CONTEXT OF …

E Dustin - 2023 - scholarscompass.vcu.edu
Multiple Sclerosis is an immune mediated disease of the CNS. MS is diagnosed through
detection of demyelinated regions. However, recent studies demonstrate that Normal …