CAD is a 1.5 MDa particle formed by hexameric association of a 250 kDa protein divided
into different enzymatic domains, each catalyzing one of the initial reactions for de novo …

The Ser-Thr kinase mammalian target of rapamycin (mTOR) controls cell growth and
metabolism by stimulating glycolysis and synthesis of proteins and lipids. To further …

CAD is a 1.5 MDa particle formed by hexameric association of a 250 kDa protein that carries
the enzymatic activities for the first three steps in the de novo biosynthesis of pyrimidine …

Novel antimalarial therapies are urgently needed for the fight against drug-resistant
parasites. The metabolism of malaria parasites in infected cells is an attractive source of …

Upregulation of CAD, the multifunctional protein that initiates and controls the de novo
biosynthesis of pyrimidines in animals, is essential for cell proliferation. Deciphering the …

CAD, the multifunctional protein initiating and controlling de novo biosynthesis of
pyrimidines in animals, self-assembles into∼ 1.5 MDa hexamers. The structures of the …

The recent discovery of several forms of higher order protein structures in cells has shifted
the paradigm of how we think about protein organization and metabolic regulation. These …

Carbamyl phosphate (CP) is well-known as an essential intermediate of pyrimidine and
arginine/urea biosynthesis. Chemically, CP can be easily synthesized from dihydrogen …

CAD, the multienzymatic protein that initiates and controls de novo synthesis of pyrimidines
in animals, associates through its aspartate transcarbamoylase (ATCase) domain into …

Allantoinase and dihydroorotase are members of the cyclic amidohydrolases family.
Allantoinase and dihydroorotase possess very similar binuclear metal centers in the active …