The key objectives of medicinal chemistry are to efficiently design and synthesize bioactive
compounds that have the potential to become safe and efficacious drugs. Most medicinal …

Natural products (NPs) inspire the design and synthesis of novel biologically relevant
chemical matter, for instance through biology‐oriented synthesis (BIOS). However, BIOS is …

Abstract Diversity Oriented Clicking (DOC) is a unified click‐approach for the modular
synthesis of lead‐like structures through application of the wide family of click …

A new generation of saturated benzene mimetics, 2‐oxabicyclo [2.1. 1] hexanes, was
developed. These compounds were designed as analogues of bicyclo [1.1. 1] pentane with …

The principles guiding the design and synthesis of bioactive compounds based on natural
product (NP) structure, such as biology-oriented synthesis (BIOS), are limited by their partial …

Fragment‐based drug discovery (FBDD) is a popular method in academia and the
pharmaceutical industry for the discovery of early lead candidates. Despite its wide‐spread …

Bioactive compound design based on natural product (NP) structure may be limited because
of partial coverage of NP‐like chemical space and biological target space. These limitations …

We describe the synthesis and biological evaluation of a new natural product‐inspired
compound class obtained by combining the conceptually complementary pseudo‐natural …

Abstract Pseudo‐natural‐product (NP) design combines natural product fragments to
provide unprecedented NP‐inspired compounds not accessible by biosynthesis, but …

Medium‐sized rings are widely considered to be under‐represented in biological screening
libraries for lead identification in medicinal chemistry. To help address this, a library of …