Diabetes is associated with an increased risk of heart failure (HF). This is commonly termed
diabetic cardiomyopathy and is often characterised by increased cardiac fibrosis …

Diabetes Mellitus (DM) is a complex disease with a significant impact in today's world.
Studies have emphasized the crucial role of genetics in DM, unraveling the distinction of …

Inflammation is a potential factor in the pathophysiology of depression. A traditional Chinese
herbal medicine, arctiin, and its aglycone, arctigenin, are the major bioactive components in …

Endothelial cells (ECs) primarily rely on glycolysis for their energy metabolism, and the final
product of glycolysis—lactate—is transferred out of cells via monocarboxylate transporter 4 …

Abstract Background Type 1 diabetes (T1D) is a chronic autoimmune disease characterized
by the progressive destruction of insulin‐production pancreatic β cells. Recently, microRNAs …

Abstract Type 1 diabetes (T1D) is characterized by an immune-mediated progressive
destruction of the insulin-producing β-cells. Proinflammatory cytokines trigger endoplasmic …

Aim To investigate the effects of adenosine kinase (ADK), a key enzyme in determining
intracellular adenosine levels, on β cells, and their underlying mechanism. Methods Genetic …

Activation of brown adipose tissue (BAT) and beige fat by cold increases energy
expenditure. Although their activation is known to be differentially regulated in part by …

Aims Previous evidence has demonstrated that oxidative stress is related to the
pathogenesis of missed abortion (MA), but the specific mechanism remains obscure. The …

The APPL1 gene encodes a protein mediating the cross-talk between adiponectin and
insulin signaling. Recently, it was found that APPL1 mutations can cause maturity onset …