Although the role of NOTCH signaling has been extensively studied in health and disease,
many questions still remain unresolved. Being crucial for tissue homeostasis, NOTCH …

Purpose N6-methyladenosine (m6A), the most abundant mRNA modification in mammals, is
involved in various biological processes. KIAA1429 is an important methyltransferase …

Abstract N 6-Methyladenosine (m6A) modification is one of the most widely distributed RNA
modifications in eukaryotes. It participates in various RNA functions and plays vital roles in …

Neuroinflammation is a well-characterized pathophysiology occurring in association with the
progression of Parkinson's disease. Characterizing the cellular and molecular basis of …

Loss of function following injury to the CNS is worsened by secondary degeneration of
neurons and glia surrounding the injury and is initiated by oxidative damage. However, it is …

The growth of glioblastoma (GBM), one of the deadliest adult cancers, is fuelled by a
subpopulation of stem/progenitor cells, which are thought to be the source of resistance and …

Surfactant protein B (SFTPB) deficiency is a fatal disease affecting newborn infants.
Surfactant is produced by alveolar type II cells which can be differentiated in vitro from …

Multiple sclerosis (MS) is a chronic inflammatory disease characterized by the formation of
demyelinated lesions in the central nervous system. At later stages of the disease repair in …

In oligodendrocytes of the vertebrate central nervous system a complex network of
transcriptional regulators is required to ensure correct and timely myelination of neuronal …

Inhibitor of DNA binding (ID) proteins are a class of helix-loop-helix (HLH) transcription
regulatory factors that act as dominant-negative antagonists of other basic HLH proteins …