Towards 4th industrial revolution efficient and sustainable continuous flow manufacturing of active pharmaceutical ingredients

CR Sagandira, S Nqeketo, K Mhlana, T Sonti… - Reaction Chemistry & …, 2022 - pubs.rsc.org
Continuous flow chemistry has opened a new paradigm in both the laboratory and
pharmaceutical industry. This review details the recently reported literature on continuous …

Application of reactor engineering concepts in continuous flow chemistry: a review

NC Neyt, DL Riley - Reaction Chemistry & Engineering, 2021 - pubs.rsc.org
The adoption of flow technology for the manufacture of chemical entities, and in particular
pharmaceuticals, has seen rapid growth over the past two decades with the technology now …

Integrated continuous pharmaceutical technologies—a review

A Domokos, B Nagy, B Szilagyi, G Marosi… - … Process Research & …, 2021 - ACS Publications
Innovation in the pharmaceutical industry has been limited for a long time to the research
and development of new active compounds; meanwhile, the structure of the production …

Making the move towards modernized greener separations: introduction of the analytical method greenness score (AMGS) calculator

MB Hicks, W Farrell, C Aurigemma, L Lehmann… - Green chemistry, 2019 - pubs.rsc.org
Green and sustainable processes to develop and manufacture pharmaceuticals using eco-
friendly and environmentally responsible means have been underway for over 25 years …

Nanofiltration‐enabled in situ solvent and reagent recycle for sustainable continuous‐flow synthesis

T Fodi, C Didaskalou, J Kupai, GT Balogh… - …, 2017 - Wiley Online Library
Solvent usage in the pharmaceutical sector accounts for as much as 90% of the overall
mass during manufacturing processes. Consequently, solvent consumption poses …

[HTML][HTML] Continuous end-to-end production of solid drug dosage forms: Coupling flow synthesis and formulation by electrospinning

A Balogh, A Domokos, B Farkas, A Farkas… - Chemical Engineering …, 2018 - Elsevier
Based on the concept of continuous manufacturing an end-to-end benchtop device was
developed unprecedented for the production of solid drug dosage forms by connecting flow …

[HTML][HTML] Inline purification in continuous flow synthesis–opportunities and challenges

J García-Lacuna, M Baumann - Beilstein Journal of Organic …, 2022 - beilstein-journals.org
Continuous flow technology has become the method of choice for many academic and
industrial researchers when developing new routes to chemical compounds of interest. With …

Isolation and characterization of efficient active compounds using high-performance centrifugal partition chromatography (CPC) from anti-inflammatory activity fraction …

HS Kim, JG Je, H An, K Baek, JM Lee, MJ Yim, SC Ko… - Marine Drugs, 2022 - mdpi.com
Ecklonia maxima is a brown seaweed, which is abundantly distributed in South Africa. This
study investigated an efficient approach using high-performance centrifugal partition …

Continuous industrial-scale centrifugal partition chromatography with automatic solvent system handling: Concept and instrumentation

L Lorántfy, D Rutterschmid, R Örkényi… - … Process Research & …, 2020 - ACS Publications
Centrifugal partition chromatography (CPC) is an emerging separation technology in
pharmaceutical and natural product purifications, reaching recently industrial-scale …

High-throughput experimentation and continuous flow evaluation of nucleophilic aromatic substitution reactions

Z Jaman, DL Logsdon, B Szilágyi… - ACS Combinatorial …, 2020 - ACS Publications
Nucleophilic aromatic substitution (SNAr) reactions were optimized using high-throughput
experimentation techniques for execution under flow conditions. A total of 3072 unique …