Neutrophils are the most abundant circulating leukocytes, being the first line of defence
against bacterial and fungal infections. However, neutrophils also contribute to tissue …

Cytokines provide cells with the ability to communicate with one another and orchestrate
complex multicellular behaviour. There is an emerging understanding of the role that …

Multiple sclerosis (MS) is a T cell-mediated autoimmune disease of the central nervous
system (CNS). Bone marrow hematopoietic stem and progenitor cells (HSPCs) rapidly …

Dopamine is well recognized as a neurotransmitter in the brain, and regulates critical
functions in a variety of peripheral systems. Growing research has also shown that …

The objective of this study is to examine IL-11-induced mechanisms of inflammatory cell
migration to the central nervous system (CNS). We report that IL-11 is produced at highest …

Neutrophils are one of the first immune cell types that are recruited to injury and infection
site. As a vital component of the immune system, neutrophils are heterogeneous immune …

Myeloperoxidase (MPO) is the most toxic enzyme found in the azurophilic granules of
neutrophils. MPO utilizes H 2 O 2 to generate hypochlorous acid (HClO) and other reactive …

Exposure to pro-inflammatory cytokines, chemokines, mitochondrial contents, and bacterial
and viral products induces neutrophils to transition from a basal state into a primed one …

Taken orally, the drug dimethyl fumarate (DMF) has been shown to improve functional
outcomes for patients with MS; however, it is unclear how DMF mediates a protective effect …

A major function of T helper (Th) 17 cells is to induce the production of factors that activate
and mobilize neutrophils. Although Th17 cells have been implicated in the pathogenesis of …