[HTML][HTML] New insights for gynecological cancer therapies: from molecular mechanisms and clinical evidence to future directions

C Zhang, Y Sheng, X Sun, Y Wang - Cancer and Metastasis Reviews, 2023 - Springer
Advanced and recurrent gynecological cancers lack effective treatment and have poor
prognosis. Besides, there is urgent need for conservative treatment for fertility protection of …

[HTML][HTML] Advances in epigenetic modifications and cervical cancer research

H Liu, H Ma, Y Li, H Zhao - Biochimica et Biophysica Acta (BBA)-Reviews …, 2023 - Elsevier
Cervical cancer (CC) is an important public health problem for women, and perspectives
and information regarding its prevention and treatment are quickly evolving. Human …

[HTML][HTML] PCDHGB7 hypermethylation-based Cervical cancer Methylation (CerMe) detection for the triage of high-risk human papillomavirus-positive women: a …

D Cao, Z Yang, S Dong, Y Li, Z Mao, Q Lu, P Xu… - BMC medicine, 2024 - Springer
Background Implementation of high-risk human papillomavirus (hrHPV) screening has
greatly reduced the incidence and mortality of cervical cancer. However, a triage strategy …

MethMarkerDB: a comprehensive cancer DNA methylation biomarker database

Z Zhu, Q Zhou, Y Sun, F Lai, Z Wang… - Nucleic Acids …, 2024 - academic.oup.com
DNA methylation plays a crucial role in tumorigenesis and tumor progression, sparking
substantial interest in the clinical applications of cancer DNA methylation biomarkers …

[HTML][HTML] The outpost against cancer: universal cancer only markers

C Qian, X Zou, W Li, Y Li, W Yu - Cancer Biology & Medicine, 2023 - ncbi.nlm.nih.gov
Cancer is the leading cause of death worldwide. Early detection of cancer can lower the
mortality of all types of cancer; however, effective early-detection biomarkers are lacking for …

[HTML][HTML] Circulating tumor cells: from new biological insights to clinical practice

X Gu, S Wei, X Lv - Signal Transduction and Targeted Therapy, 2024 - nature.com
The primary reason for high mortality rates among cancer patients is metastasis, where
tumor cells migrate through the bloodstream from the original site to other parts of the body …

[HTML][HTML] Hypermethylated PCDHGB7 as a biomarker for early detection of endometrial cancer in endometrial brush samples and cervical scrapings

J Yuan, Z Mao, Q Lu, P Xu, C Wang, X Xu… - Frontiers in Molecular …, 2022 - frontiersin.org
Endometrial cancer (EC) is one of the most common gynecologic cancers in developed
countries. Presently, it is imperative to develop a reliable, noninvasive, or minimally invasive …

[HTML][HTML] Diagnosis of malignant body fluids via cancer-universal methylation in cell-free DNA

Z Mao, S Dong, Y Yan, C Wang, W Li, L Wang, C Qian… - JCI insight, 2024 - ncbi.nlm.nih.gov
BACKGROUND Differentiating malignant from nonmalignant body fluids remains a clinical
challenge because of the unsatisfying performance of conventional cytology. We aimed to …

[HTML][HTML] Hypermethylated TAGMe as a universal-cancer-only methylation marker and its application in diagnosis and recurrence monitoring of urothelial carcinoma

Z Yang, Q Chen, S Dong, P Xu, W Zheng, Z Mao… - Journal of Translational …, 2024 - Springer
Background Urothelial carcinoma (UC) is the second most common urological malignancy.
Despite numerous molecular markers have been evaluated during the past decades, no …

[HTML][HTML] Mutually exclusive epigenetic modification on SIX6 with hypermethylation for precancerous stage and metastasis emergence tracing

S Dong, Z Yang, P Xu, W Zheng, B Zhang… - … and Targeted Therapy, 2022 - nature.com
Aberrant DNA methylation gets involved in cancer initiation, progression, and recurrence,
which in turn makes it an ideal cancer biomarker. Various methylation markers or their …