A comprehensive review on peptide-bearing biomaterials: From ex situ to in situ self-assembly

SY Qin, JQ Feng, YJ Cheng, WL Liu, AQ Zhang… - Coordination Chemistry …, 2024 - Elsevier
In the last few decades, we have witnessed the great advances of molecular self-assembly
in biomedical applications. Among the building blocks for molecular self-assembly, peptide …

Alkaline phosphatase: a reliable endogenous partner for drug delivery and diagnostics

B Le‐Vinh, ZB Akkuş‐Dağdeviren… - Advanced …, 2022 - Wiley Online Library
Since the 1960s the membrane‐bound enzyme alkaline phosphatase (ALP) has been
utilized in drug delivery. As it cleaves phosphate substructures from drugs, auxiliary agents …

Intranuclear nanoribbons for selective killing of osteosarcoma cells

S Liu, Q Zhang, H He, M Yi, W Tan… - Angewandte Chemie …, 2022 - Wiley Online Library
Herein, we show intranuclear nanoribbons formed upon dephosphorylation of leucine‐rich L‐
or D‐phosphopeptide catalyzed by alkaline phosphatase (ALP) to selectively kill …

In Situ Self‐Assembly of Bispecific Peptide for Cancer Immunotherapy

MD Wang, GT Lv, HW An, NY Zhang… - Angewandte Chemie …, 2022 - Wiley Online Library
Precise and effective manipulation of protein functions still faces tremendous challenges.
Herein we report a programmable peptide molecule, consisted of targeting and self …

Granzyme B turns nanoparticle fluorescence “on” for imaging cytotoxic T lymphocyte activity in vivo

L Xu, N Liu, W Zhan, Y Deng, Z Chen, X Liu, G Gao… - ACS …, 2022 - ACS Publications
Cytotoxic T lymphocytes (CTLs) are important immune cells, and their activation is a key step
for cancer immunotherapy. Precise evaluation of CTL activity in vivo provides a powerful tool …

An injectable co-assembled hydrogel blocks reactive oxygen species and inflammation cycle resisting myocardial ischemia-reperfusion injury

X Liao, X Song, J Li, L Li, X Fan, Q Qin, C Zhong… - Acta biomaterialia, 2022 - Elsevier
The overproduction of reactive oxygen species (ROS) and burst of inflammation following
cardiac ischemia–reperfusion (I/R) are the leading causes of cardiomyocyte injury …

In vivo self‐assembly induced cell membrane phase separation for improved peptide drug internalization

RC Guo, XH Zhang, PS Fan, BL Song… - Angewandte Chemie …, 2021 - Wiley Online Library
Therapeutic peptides have been widely concerned, but their efficacy is limited by the
inability to penetrate cell membranes, which is a key bottleneck in peptide drugs delivery …

Self‐assembled peptide‐based nanodrugs: molecular design, synthesis, functionalization, and targeted tumor bioimaging and biotherapy

X Luan, H Kong, P He, G Yang, D Zhu, L Guo, G Wei - Small, 2023 - Wiley Online Library
Functional nanomaterials as nanodrugs based on the self‐assembly of inorganics,
polymers, and biomolecules have showed wide applications in biomedicine and tissue …

Structural determinants of stimuli-responsiveness in amphiphilic macromolecular nano-assemblies

H Liu, HH Lu, Y Alp, R Wu, S Thayumanavan - Progress in Polymer …, 2024 - Elsevier
Stimuli-responsive nano-assemblies from amphiphilic macromolecules could undergo
controlled structural transformations and generate diverse macroscopic phenomenon under …

Self-amplifying assembly of peptides in macrophages for enhanced inflammatory treatment

Y Song, M Li, N Song, X Liu, G Wu… - Journal of the …, 2022 - ACS Publications
Enzyme-regulated in situ self-assembly of peptides represents one versatile strategy in the
creation of theranostic agents, which, however, is limited by the strong dependence on …