The mammalian skeletal system is densely innervated by both neural and vascular
networks. Peripheral nerves in the skeleton include sensory and sympathetic nerves. The …

Tissue damage can resolve completely through healing and regeneration, or can produce
permanent scarring and loss of function. The response to tissue damage varies across …

Bone is richly innervated by nerve growth factor–responsive (NGF-responsive) tropomyosin
receptor kinase A–expressing (TrKa-expressing) sensory nerve fibers, which are required …

The zebrafish fin provides a valuable model to study the epimorphic type of regeneration,
whereby the amputated part of the appendage is nearly perfectly replaced. To accomplish …

Pain is a central feature of soft tissue trauma, which under certain contexts, results in
aberrant osteochondral differentiation of tissue-specific stem cells. Here, the role of sensory …

The immune system has a critical role in orchestrating tissue healing. As a result,
regenerative strategies that control immune components have proved effective,. This is …

The ability of vertebrates to regenerate amputated appendages is increasingly well-
understood at the cellular level. Cells mediating an innate immune response and …

Despite the identification of numerous regulators of regeneration in different animal models,
a fundamental question remains: why do some wounds trigger the full regeneration of lost …

Peripheral neurons terminate at the surface of tendons partly to relay nociceptive pain
signals; however, the role of peripheral nerves in tendon injury and repair remains unclear …

The flat bones of the skull are densely innervated during development, but little is known
regarding their role during repair. We describe a neurotrophic mechanism that directs …