First discovered as a structure-specific endonuclease that evolved to cut at the base of
single-stranded flaps, flap endonuclease (FEN1) is now recognized as a central component …

FAN1 encodes a DNA repair nuclease. Genetic deficiencies, copy number variants, and
single nucleotide variants of FAN1 have been linked to karyomegalic interstitial nephritis …

An increased DNA repair capacity is associated with drug resistance and limits the efficacy
of chemotherapy in breast cancers. Flap endonuclease 1 (FEN1) participates in various …

OBJECTIVE Metformin is used as a first-line oral treatment for type 2 diabetes (T2D).
However, the underlying mechanism is not fully understood. Here, we aimed to …

FEN1 has key roles in Okazaki fragment maturation during replication, long patch base
excision repair, rescue of stalled replication forks, maintenance of telomere stability and …

The integrity of the genome is under constant threat of environmental and endogenous
agents that cause DNA damage. Endogenous damage is particularly pervasive, occurring at …

To avoid genome instability, DNA repair nucleases must precisely target the correct
damaged substrate before they are licensed to incise. Damage identification is a challenge …

Dear Editor, Neuroblastoma is the most common non-central nerve system (CNS) solid
tumor in pediatrics [1]. Neuroblastoma accounts for approximately 8% of all pediatric …

Flap endonuclease 1 (FEN1) plays a crucial role in both DNA replication and damage
repair. In this study, FEN1 expression and its clinical-pathologic significance in non–small …

Osteoporosis is characterized by low bone mineral density (BMD). The advancement of high-
throughput technologies and integrative approaches provided an opportunity for …