Determination of the experimental nucleation rate for crystallization in solution has been
acknowledged as an important topic for a long time, as it improves the design and control of …

The solid-state hydration of salts has gained particular interest within the frame of
thermochemical energy storage. In this work, the water vapor pressure–temperature (p–T) …

This work presents a generalized framework to assess the accuracy of methods to estimate
primary and secondary nucleation rates from experimental data. The crystallization process …

Crystal nucleation from solution is of central importance in the chemical and biological
sciences. Linking nucleation kinetics to the properties of solutes and solvents remains a …

The effect of fluid shear on the primary nucleation of paracetamol in water, isopropyl alcohol,
and acetonitrile was investigated. First, experiments were performed with a Taylor–Couette …

Scaling up and technology transfer of crystallization processes have been and continue to
be a challenge. This is often due to the stochastic nature of primary nucleation, various scale …

Various biopharmaceutical products are distributed as freeze-dried formulations in vials.
Minimizing batch heterogeneity, which refers to the variability of relevant properties among …

The stochastic nature of ice nucleation presents a major challenge in freezing and freeze-
drying processes of biopharmaceuticals in vials. During freezing, nucleation events occur in …

Insight into nucleation kinetics and other nucleation parameters can be obtained from
probability distributions of induction time measurements in combination with the classical …

Ostwald's rule remains a long standing guide to crystallisation in polymorphic systems. It is
often assumed that this rule has its origins in nucleation processes that favour metastable …