CLC anion transporters are found in all phyla and form a gene family of eight members in
mammals. Two CLC proteins, each of which completely contains an ion translocation …

Fermentative organs such as the caecum, the colon, and the rumen have evolved to
produce and absorb energy rich short chain fatty acids (SCFA) from otherwise indigestible …

Two-pore domain (K2P) K+ channels are major regulators of excitability that endow cells
with an outwardly rectifying background" leak" conductance. In some K2P channels, strong …

ClC-2 transports chloride ions across plasma membranes and plays critical roles in cellular
homeostasis. Its dysfunction is involved in diseases including leukodystrophy and primary …

CLC channels and transporters conduct or transport various kinds of anions, with the
exception of fluoride, which acts as an effective inhibitor. Here, we performed sub …

Volume-regulated anion channels (VRACs) are crucial for cell volume regulation and have
various roles in physiology and pathology. VRACs were recently discovered to be formed by …

Abstract TMEM16A (ANO1), the pore-forming subunit of calcium-activated chloride
channels, regulates several physiological and pathophysiological processes such as …

Numerous essential physiological processes depend on the TMEM16A-mediated Ca2+-
activated chloride fluxes. Extensive structure–function studies have helped to elucidate the …

CLC-2 is a voltage-gated chloride channel that contributes to electrical excitability and ion
homeostasis in many different tissues. Among the nine mammalian CLC homologs, CLC-2 …

Key points The calcium‐activated chloride channel TMEM16A provides a pathway for
chloride ion movements that are key in preventing polyspermy, allowing fluid secretion …