The regulation of transcription in memory consolidation

CM Alberini, ER Kandel - Cold Spring Harbor …, 2015 - cshperspectives.cshlp.org
De novo transcription of DNA is a fundamental requirement for the formation of long-term
memory. It is required during both consolidation and reconsolidation, the posttraining and …

The restless engram: consolidations never end

Y Dudai - Annual review of neuroscience, 2012 - annualreviews.org
Memory consolidation is the hypothetical process in which an item in memory is transformed
into a long-term form. It is commonly addressed at two complementary levels of description …

Gut microbiota regulate Alzheimer's disease pathologies and cognitive disorders via PUFA-associated neuroinflammation

C Chen, J Liao, Y Xia, X Liu, R Jones, J Haran… - Gut, 2022 - gut.bmj.com
Objective This study is to investigate the role of gut dysbiosis in triggering inflammation in
the brain and its contribution to Alzheimer's disease (AD) pathogenesis. Design We …

Spatio-temporal transcriptome of the human brain

HJ Kang, YI Kawasawa, F Cheng, Y Zhu, X Xu, M Li… - Nature, 2011 - nature.com
Brain development and function depend on the precise regulation of gene expression.
However, our understanding of the complexity and dynamics of the transcriptome of the …

SHANK3 and IGF1 restore synaptic deficits in neurons from 22q13 deletion syndrome patients

A Shcheglovitov, O Shcheglovitova, M Yazawa… - Nature, 2013 - nature.com
Phelan–McDermid syndrome (PMDS) is a complex neurodevelopmental disorder
characterized by global developmental delay, severely impaired speech, intellectual …

[HTML][HTML] Epigenetic priming of memory updating during reconsolidation to attenuate remote fear memories

J Gräff, NF Joseph, ME Horn, A Samiei, J Meng, J Seo… - Cell, 2014 - cell.com
Traumatic events generate some of the most enduring forms of memories. Despite the
elevated lifetime prevalence of anxiety disorders, effective strategies to attenuate long-term …

Local autocrine plasticity signaling in single dendritic spines by insulin-like growth factors

X Tu, A Jain, P Parra Bueno, H Decker, X Liu… - Science …, 2023 - science.org
The insulin superfamily of peptides is essential for homeostasis as well as neuronal
plasticity, learning, and memory. Here, we show that insulin-like growth factors 1 and 2 (IGF1 …

The role of reconsolidation and the dynamic process of long-term memory formation and storage

CM Alberini - Frontiers in behavioral neuroscience, 2011 - frontiersin.org
It is becoming increasingly clear that the processes of memory formation and storage are
exquisitely dynamic. Elucidating the nature and temporal evolution of the biological changes …

The protective effects of osteocyte‐derived extracellular vesicles against Alzheimer's disease diminished with aging

YL Jiang, ZX Wang, XX Liu, MD Wan, YW Liu… - Advanced …, 2022 - Wiley Online Library
Both Alzheimer's disease (AD) and osteoporosis (OP) are common age‐associated
degenerative diseases and are strongly correlated with clinical epidemiology. However …

Updating memories—the role of prediction errors in memory reconsolidation

MTJ Exton-McGuinness, JLC Lee… - Behavioural brain research, 2015 - Elsevier
Memories are not static imprints of past experience, but rather are dynamic entities which
enable us to predict outcomes of future situations and inform appropriate behaviours. In …