Understanding the versatile roles and applications of EpCAM in cancers: from bench to bedside
Y Liu, Y Wang, S Sun, Z Chen, S Xiang, Z Ding… - … hematology & oncology, 2022 - Springer
Epithelial cell adhesion molecule (EpCAM) functions not only in physiological processes but
also participates in the development and progression of cancer. In recent decades …
also participates in the development and progression of cancer. In recent decades …
Harnessing epithelial-mesenchymal plasticity to boost cancer immunotherapy
Immune checkpoint blockade (ICB) therapy is a powerful option for cancer treatment.
Despite demonstrable progress, most patients fail to respond or achieve durable responses …
Despite demonstrable progress, most patients fail to respond or achieve durable responses …
Heterogeneous plasma cells and long-lived subsets in response to immunization, autoantigen and microbiota
Durable antibody immunity depends on long-lived plasma cells (LLPCs) that primarily reside
in the bone marrow (BM). However, due to LLPC rarity, it has not been possible to define …
in the bone marrow (BM). However, due to LLPC rarity, it has not been possible to define …
MicroRNA-200c attenuates the tumor-infiltrating capacity of macrophages
R Raue, AC Frank, DC Fuhrmann, P de la Cruz-Ojeda… - Biology, 2022 - mdpi.com
Simple Summary The tumor microenvironment determines the prognosis and outcome for
cancer patients. Herein, tumor-associated macrophages are not only highly abundant, but …
cancer patients. Herein, tumor-associated macrophages are not only highly abundant, but …
miRNAs in regulation of tumor microenvironment, chemotherapy resistance, immunotherapy modulation and miRNA therapeutics in cancer
miRNAs are 20–22 long nucleotide non-coding ribonucleic acid molecules critical to the
modulation of molecular pathways. Immune evasion and the establishment of a suitable …
modulation of molecular pathways. Immune evasion and the establishment of a suitable …
Remodeling the tumor immune microenvironment with oncolytic viruses expressing miRNAs
G St-Cyr, D Penarroya, L Daniel, H Giguère… - Frontiers in …, 2023 - frontiersin.org
MiRNAs (miRNA, miR) play important functions in the tumor microenvironment (TME) by
silencing gene expression through RNA interference. They are involved in regulating both …
silencing gene expression through RNA interference. They are involved in regulating both …
Recent process of using nanoparticles in the T cell-based immunometabolic therapy
B Chen, Y Li, H Wang - Nanotechnology Reviews, 2024 - degruyter.com
Immunotherapy is currently the main treatment for malignant tumors by activating immune
cell. Metabolic reprogramming in tumor microenvironment can greatly affect the function of …
cell. Metabolic reprogramming in tumor microenvironment can greatly affect the function of …
Rapid Screening of CAR T Cell Functional Improvement Strategies by Highly Multiplexed Single-Cell Secretomics
D Slavkovic-Lukic, J Fioravanti, A Martín-Santos… - … : Methods and Protocols, 2023 - Springer
The functional fitness of CAR T cells plays a crucial role in determining their clinical efficacy.
Several strategies are being explored to increase cellular fitness, but screening these …
Several strategies are being explored to increase cellular fitness, but screening these …
De novo generation of T-cell receptors with desired epitope-binding property by leveraging a pre-trained large language model
Generating T-cell receptors (TCRs) with desired epitope-binding properties is a fundamental
step in the development of immunotherapies, yet heavily relies on laborious and expensive …
step in the development of immunotherapies, yet heavily relies on laborious and expensive …
The application of epigenetics in CAR-T therapy
X Zhang - Advances in Engineering Technology …, 2022 - madison-proceedings.com