Why won't it stop? The dynamics of benzodiazepine resistance in status epilepticus

RJ Burman, RE Rosch, JM Wilmshurst, A Sen… - Nature Reviews …, 2022 - nature.com
Status epilepticus is a life-threatening neurological emergency that affects both adults and
children. Approximately 36% of episodes of status epilepticus do not respond to the current …

[HTML][HTML] Role of NKCC1 and KCC2 in epilepsy: from expression to function

R Liu, J Wang, S Liang, G Zhang, X Yang - Frontiers in neurology, 2020 - frontiersin.org
As a main inhibitory neurotransmitter in the central nervous system, γ-aminobutyric acid
(GABA) activates chloride-permeable GABAa receptors (GABAa Rs) and induces chloride …

Gelastic epilepsy and hypothalamic hamartomas: neuroanatomical analysis of brain lesions in 100 patients

J Parvizi, S Le, BL Foster, B Bourgeois, JJ Riviello… - Brain, 2011 - academic.oup.com
Hypothalamic hamartomas present with isolated fits of ictal laughter (gelastic epilepsy) or a
combination of gelastic and other types of seizures. Many of these patients also suffer from …

Hypothalamic hamartoma: Neuropathology and epileptogenesis

JF Kerrigan, A Parsons, C Tsang, K Simeone… - …, 2017 - Wiley Online Library
Hypothalamic hamartomas (HH s) are congenital malformations of the ventral hypothalamus
resulting in treatment‐resistant epilepsy and are intrinsically epileptogenic for the gelastic …

A region‐specific modulation of sleep slow waves on interictal epilepsy markers in focal epilepsy

C Chen, Y Wang, L Ye, J Xu, W Ming, X Liu, L Hu… - …, 2023 - Wiley Online Library
Objective Sleep strongly activates interictal epileptic activity through an unclear mechanism.
We investigated how scalp sleep slow waves (SSWs), whose positive and negative half …

[HTML][HTML] Voltage-dependent calcium channel signaling mediates GABAA receptor-induced migratory activation of dendritic cells infected by Toxoplasma gondii

S Kanatani, JM Fuks, EB Olafsson, L Westermark… - PLoS …, 2017 - journals.plos.org
The obligate intracellular parasite Toxoplasma gondii exploits cells of the immune system to
disseminate. Upon T. gondii-infection, γ–aminobutyric acid (GABA)/GABAA receptor …

The gelastic seizures-hypothalamic hamartoma syndrome: facts, hypotheses, and perspectives

S Striano, L Santulli, M Ianniciello, M Ferretti… - Epilepsy & Behavior, 2012 - Elsevier
Hypothalamic hamartoma (HH) can be associated with a wide spectrum of epileptic
conditions, ranging from a mild form with seizures characterized by urge to laugh and no …

Hypothalamic hamartomas. Part 1. Clinical, neuroimaging, and neurophysiological characteristics

S Mittal, M Mittal, JL Montes, JP Farmer… - Neurosurgical focus, 2013 - thejns.org
Hypothalamic hamartomas are uncommon but well-recognized developmental
malformations that are classically associated with gelastic seizures and other refractory …

[HTML][HTML] Amyloid precursor protein (APP) and GABAergic neurotransmission

BL Tang - Cells, 2019 - mdpi.com
The amyloid precursor protein (APP) is the parent polypeptide from which amyloid-beta (Aβ)
peptides, key etiological agents of Alzheimer's disease (AD), are generated by sequential …

Advances in epileptic network findings of hypothalamic hamartomas

D Wang, D Lu, M Zhang, A Dai, G Jin… - Journal of Central …, 2024 - journals.sagepub.com
Hypothalamic hamartomas (HHs) are congenital developmental malformations located in
the hypothalamus. They are associated with a characteristic clinical manifestation known as …