Applications of phyto-nanotechnology for the treatment of neurodegenerative disorders

T Bhattacharya, GAB Soares, H Chopra, MM Rahman… - Materials, 2022 - mdpi.com
The strategies involved in the development of therapeutics for neurodegenerative disorders
are very complex and challenging due to the existence of the blood-brain barrier (BBB), a …

microRNA dysregulation in neurodegenerative diseases: A systematic review

CA Juźwik, SS Drake, Y Zhang, N Paradis-Isler… - Progress in …, 2019 - Elsevier
While the root causes for individual neurodegenerative diseases are distinct, many shared
pathological features and mechanisms contribute to neurodegeneration across diseases …

The role of noncoding RNAs in Parkinson's disease: biomarkers and associations with pathogenic pathways

MC Kuo, SCH Liu, YF Hsu, RM Wu - Journal of biomedical science, 2021 - Springer
The discovery of various noncoding RNAs (ncRNAs) and their biological implications is a
growing area in cell biology. Increasing evidence has revealed canonical and noncanonical …

Role of MicroRNAs in Parkinson's disease

SY Goh, YX Chao, ST Dheen, EK Tan… - International journal of …, 2019 - mdpi.com
Parkinson's disease (PD) is a disabling neurodegenerative disease that manifests with
resting tremor, bradykinesia, rigidity and postural instability. Since the discovery of …

MicroRNA dysregulation in Parkinson's disease: a narrative review

YH Nies, NH Mohamad Najib, WL Lim… - Frontiers in …, 2021 - frontiersin.org
Parkinson's disease (PD) is a severely debilitating neurodegenerative disease, affecting the
motor system, leading to resting tremor, cogwheel rigidity, bradykinesia, walking and gait …

Biomarkers in Parkinson's disease

A Surguchov - … diseases biomarkers: Towards translating research to …, 2022 - Springer
Parkinson's disease (PD) is the second most common neurodegenerative disorder, with a
documented significant increase in its prevalence in the past three decades. Both …

Circulating miRNAs as diagnostic biomarkers for Parkinson's disease

AE Roser, L Caldi Gomes, J Schünemann… - Frontiers in …, 2018 - frontiersin.org
Parkinson's disease (PD) is the second most common neurodegenerative disorder
worldwide. Its main neuropathological hallmarks are the degeneration of dopaminergic …

Integration of miRNA's theranostic potential with nanotechnology: promises and challenges for Parkinson's disease therapeutics

KP Tryphena, G Singh, N Jain, P Famta… - Mechanisms of Ageing …, 2023 - Elsevier
Despite the wide research going on in Parkinson's disease (PD), the burden of PD still
remains high and continues to increase. The current drugs available for the treatment of PD …

Pharmacokinetics and pharmacodynamics of a single dose Nilotinib in individuals with Parkinson's disease

FL Pagan, ML Hebron, B Wilmarth… - Pharmacology …, 2019 - Wiley Online Library
Nilotinib is a broad‐based tyrosine kinase inhibitor with the highest affinity to inhibit Abelson
(c‐Abl) and discoidin domain receptors (DDR 1/2). Preclinical evidence indicates that …

Meta‐analyses identify differentially expressed microRNAs in Parkinson's disease

J Schulz, P Takousis, I Wohlers, IOG Itua… - Annals of …, 2019 - Wiley Online Library
Objective MicroRNA (miRNA)‐mediated (dys) regulation of gene expression has been
implicated in Parkinson's disease (PD), although results of miRNA expression studies …