[PDF][PDF] The variant gambit: COVID-19's next move

JA Plante, BM Mitchell, KS Plante, K Debbink… - Cell host & …, 2021 - cell.com
More than a year after its emergence, COVID-19, the disease caused by SARS-CoV-2,
continues to plague the world and dominate our daily lives. Even with the development of …

[HTML][HTML] Structural and functional properties of SARS-CoV-2 spike protein: potential antivirus drug development for COVID-19

Y Huang, C Yang, X Xu, W Xu, S Liu - Acta Pharmacologica Sinica, 2020 - nature.com
Coronavirus disease 2019 is a newly emerging infectious disease currently spreading
across the world. It is caused by a novel coronavirus, severe acute respiratory syndrome …

[PDF][PDF] SARS-CoV-2 breakthrough infections elicit potent, broad, and durable neutralizing antibody responses

AC Walls, KR Sprouse, JE Bowen, A Joshi, N Franko… - Cell, 2022 - cell.com
Although infections among vaccinated individuals lead to milder COVID-19 symptoms
relative to those in unvaccinated subjects, the specificity and durability of antibody …

Broad betacoronavirus neutralization by a stem helix–specific human antibody

D Pinto, MM Sauer, N Czudnochowski, JS Low… - Science, 2021 - science.org
The spillovers of betacoronaviruses in humans and the emergence of severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2) variants highlight the need for broad …

Receptor binding and priming of the spike protein of SARS-CoV-2 for membrane fusion

DJ Benton, AG Wrobel, P Xu, C Roustan, SR Martin… - Nature, 2020 - nature.com
Infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is initiated by
virus binding to the ACE2 cell-surface receptors,,–, followed by fusion of the virus and cell …

Thrombocytopathy and endotheliopathy: crucial contributors to COVID-19 thromboinflammation

SX Gu, T Tyagi, K Jain, VW Gu, SH Lee… - Nature Reviews …, 2021 - nature.com
The core pathology of coronavirus disease 2019 (COVID-19) is infection of airway cells by
severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that results in excessive …

[PDF][PDF] SARS-CoV-2 infection depends on cellular heparan sulfate and ACE2

TM Clausen, DR Sandoval, CB Spliid, J Pihl… - Cell, 2020 - cell.com
We show that SARS-CoV-2 spike protein interacts with both cellular heparan sulfate and
angiotensin-converting enzyme 2 (ACE2) through its receptor-binding domain (RBD) …

The glycosylation in SARS-CoV-2 and its receptor ACE2

Y Gong, S Qin, L Dai, Z Tian - Signal Transduction and Targeted …, 2021 - nature.com
Abstract Coronavirus disease 2019 (COVID-19), a highly infectious disease caused by
severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has infected more than …

Beyond shielding: the roles of glycans in the SARS-CoV-2 spike protein

L Casalino, Z Gaieb, JA Goldsmith, CK Hjorth… - ACS central …, 2020 - ACS Publications
The ongoing COVID-19 pandemic caused by severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2) has resulted in more than 28,000,000 infections and 900,000 …

[PDF][PDF] Structures of human antibodies bound to SARS-CoV-2 spike reveal common epitopes and recurrent features of antibodies

CO Barnes, AP West, KE Huey-Tubman… - Cell, 2020 - cell.com
Neutralizing antibody responses to coronaviruses mainly target the receptor-binding domain
(RBD) of the trimeric spike. Here, we characterized polyclonal immunoglobulin Gs (IgGs) …