The E3 ubiquitin ligase WWP1 (WW Domain-containing E3 Ubiquitin Protein Ligase 1) is a
member of the HECT (Homologous to the E6-associated protein Carboxyl Terminus) E3 …

Ubiquitination, a post-translational modification that involves a covalent attachment of
ubiquitin to a protein substrate, is essential for cellular homeostatic maintenance. At the end …

Emerging evidence demonstrates that WW domain-containing E3 ubiquitin protein ligase 1
(WWP1) participates into carcinogenesis and tumor progression. In this review article, we …

Huntington's disease (HD) is a neurodegenerative disorder caused by a CAG repeat
expansion in the N-terminus of the HTT gene. The CAG repeat expansion translates into a …

Transforming growth factor β (TGFβ) is a secreted growth and differentiation factor that
influences vital cellular processes like proliferation, adhesion, motility, and apoptosis …

The initial experiments performed by Rose, Hershko, and Ciechanover describing the
identification of a specific degradation signal in short-lived proteins paved the way to the …

The connexins constitute a family of integral membrane proteins that form intercellular
channels, enabling adjacent cells to directly exchange ions and small molecules. The …

The HECT family of E3 ubiquitin ligase is divided into three subfamilies: the NEDD4, the
HERC, and the 'other'. Previous studies have mostly targeted members of the NEDD4 …

Dishevelled is a pivot in Wnt signal transduction, controlling both β-catenin-dependent
transcription to specify proliferative cell fates, and cell polarity and other non-nuclear events …

WW domain-containing E3 ubiquitin protein ligase 1 (WWP1) is a member of C2-WW-HECT
E3 ligase family. Although it may execute carcinostatic actions in some scenarios, WWP1 …