Epigenetic genes and epilepsy—emerging mechanisms and clinical applications

KMJ Van Loo, GL Carvill, AJ Becker… - Nature Reviews …, 2022 - nature.com
An increasing number of epilepsies are being attributed to variants in genes with epigenetic
functions. The products of these genes include factors that regulate the structure and …

A review of non-invasive drug delivery through respiratory routes

YB Zhang, D Xu, L Bai, YM Zhou, H Zhang, YL Cui - Pharmaceutics, 2022 - mdpi.com
With rapid and non-invasive characteristics, the respiratory route of administration has
drawn significant attention compared with the limitations of conventional routes. Respiratory …

Genetic testing and counseling for the unexplained epilepsies: an evidence‐based practice guideline of the National Society of Genetic Counselors

L Smith, J Malinowski, S Ceulemans… - Journal of Genetic …, 2023 - Wiley Online Library
Epilepsy, defined by the occurrence of two or more unprovoked seizures or one unprovoked
seizure with a propensity for others, affects 0.64% of the population and can lead to …

Shared genetics and causality underlying epilepsy and attention-deficit hyperactivity disorder

Y Wu, Y Li, J Zhu, J Long - Psychiatry research, 2022 - Elsevier
The prevalence of attention deficit hyperactivity disorder (ADHD) in patients with epilepsy
was much higher than prevalence in general population, and vice versa. The mechanisms …

Contribution of non-selective membrane channels and receptors in epilepsy

C García-Rodríguez, ID Bravo-Tobar, Y Duarte… - Pharmacology & …, 2022 - Elsevier
Overcoming refractory epilepsy's resistance to the combination of antiepileptic drugs (AED),
mitigating side effects, and preventing sudden unexpected death in epilepsy are critical …

Therapeutic options for childhood absence epilepsy

VE Rinaldi, G Di Cara, E Mencaroni, A Verrotti - Pediatric reports, 2021 - mdpi.com
Childhood absence epilepsy (CAE) is a common pediatric generalized epileptic syndrome.
Although it is traditionally considered as a benign self-limited condition, the apparent benign …

Seizures and epilepsy in childhood

M Gogou, JH Cross - CONTINUUM: Lifelong Learning in …, 2022 - journals.lww.com
Seizures and Epilepsy in Childhood : CONTINUUM: Lifelong Learning in Neurology Account
Register Activate Subscription Help Subscribe American Academy of Neurology Login Journal …

Genetic testing in children with developmental and epileptic encephalopathies: a review of advances in epilepsy genomics

YT Chang, SY Hong, WD Lin, CH Lin, SS Lin, FJ Tsai… - Children, 2023 - mdpi.com
Advances in disease-related gene discovery have led to tremendous innovations in the field
of epilepsy genetics. Identification of genetic mutations that cause epileptic …

Identifying genetic factors of polycystic ovary syndrome in women with epilepsy: a whole-genome sequencing study

W Lai, Y Wu, L Sha, Q Lai, X Yang, F Ai, Q Zhang… - …, 2024 - karger.com
Introduction: Women with epilepsy (WWE) are more likely to develop reproductive endocrine
disorders, especially polycystic ovary syndrome (PCOS). This study aimed to explore the …

Variation in prognosis and treatment outcome in juvenile myoclonic epilepsy: a Biology of Juvenile Myoclonic Epilepsy Consortium proposal for a practical definition …

G Rubboli, CP Beier, KK Selmer… - Brain …, 2023 - academic.oup.com
Reliable definitions, classifications and prognostic models are the cornerstones of stratified
medicine, but none of the current classifications systems in epilepsy address prognostic or …