The obesity epidemic represents a critical public health issue worldwide, as it is a vital risk
factor for many diseases, including type 2 diabetes (T2D) and cardiovascular disease …

Abstract N6-methyladenosine (m6A) modification plays important roles in bioprocesses and
diseases. AlkB homolog 5 (ALKBH5) is one of two m6A demethylases. Here, we reveal that …

Summary Polycomb repressive complex 2 (PRC2) is reported to bind to many RNAs and
has become a central player in reports of how long non-coding RNAs (lncRNAs) regulate …

Circular RNAs (circRNAs) are genome transcripts that are produced from back-splicing of
specific regions of pre-mRNA. These single-stranded RNA molecules are widely expressed …

Human antigen R (HuR) is an essential regulator of RNA metabolism, but its function in
metabolism remains unclear. This study identifies HuR as a major repressor during …

Interplay between energy-storing white adipose cells and thermogenic beige adipocytes
contributes to obesity and insulin resistance. Irrespective of specialized niche, adipocytes …

The mechanisms by which feeding and fasting drive rhythmic gene expression for
physiological adaptation to daily rhythm in nutrient availability are not well understood. Here …

DNA that controls gene expression (eg enhancers, promoters) has seemed almost never to
be conserved between distantly related animals, like vertebrates and arthropods. This is …

Endocrine therapy is standard treatment for estrogen receptor (ER)-positive breast cancer,
yet long-term treatment often causes acquired resistance, which results in recurrence and …

Paraspeckles are subnuclear RNA–protein structures that are implicated in important
processes including cellular stress response, differentiation, and cancer progression …