Biological membranes constitute boundaries of cells and cell organelles. These membranes
are soft fluid interfaces whose thermodynamic states are dictated by bending moduli …

In this review, we describe the application of experimental data and modeling of intracellular
endocytic trafficking mechanisms with a focus on the process of clathrin-mediated …

In eukaryotic cells, the internalization of extracellular cargo via the endocytic machinery is an
important regulatory process required for many essential cellular functions. The role of …

We present an equilibrium model for quantifying the effect of glycocalyx in mediating the
interaction of functionalized nanocarriers with endothelial cells. In this model, nanocarrier …

Curvature-sensing and curvature-remodeling proteins, such as Amphiphysin, Epsin, and
Exo70, are known to reshape cell membranes, and this remodeling event is essential for key …

This review discusses current progress and future challenges in the numerical modeling of
targeted drug delivery using functionalized nanocarriers (NC). Antibody coated nanocarriers …

In intracellular trafficking, a definitive understanding of the interplay between protein binding
and membrane morphology remains incomplete. The authors describe a computational …

We describe a hierarchical multiscale computational approach based on molecular
dynamics simulations, free energy-based molecular docking simulations, deterministic …

The membrane-surface migration of curvature-inducing proteins in response to membrane
curvature gradients has been investigated using Monte Carlo simulations of a curvilinear …

In various biological processes such as endocytosis and caveolae formation, the cell
membrane is locally deformed into curved morphologies. Previous models to study …