Simple Summary Acquired resistance to chemotherapy by cancer cells is the predominant
factor in chemotherapy failure, which ultimately leads to disease progression and death …

Adrenocortical carcinoma is a rare malignancy with an annual worldwide incidence of 1–2
cases per 1 million and a 5-year survival rate of< 60%. Although adrenocortical carcinoma is …

Apoptosis is critical for maintaining bodily homeostasis and produces a large number of
apoptotic extracellular vesicles (apoEVs). Several types of cancer cells display reduced …

Fas ligand (FasL), expressed on the surface of activated cytotoxic T lymphocytes (CTLs), is
the physiological ligand for the cell surface death receptor, Fas. The Fas-FasL engagement …

Colorectal cancer, especially liver metastasis, is still a challenge worldwide. Traditional
treatment such as surgery, chemotherapy and radiotherapy have been difficult to be further …

Colorectal cancer (CRC) is one of the high incident and lethal malignant tumors, and most of
the patients are diagnosed at an advanced stage. The treatment of CRC mainly includes …

Simple Summary Adrenocortical carcinoma is a rare but aggressive malignancy with poor
outcomes even for patients with early-stage disease. Several immunotherapy clinical trials …

Simple Summary Alternative splicing (AS) produces multiple mRNA isoforms from a gene to
make a large number of proteins. Fas (Apo-1/CD95) pre-mRNA, a member of TNF receptor …

The ability of FasL/CD95L to induce apoptosis in various Fas/CD95-expressing cells has
been described in the context of hematopoiesis or thymic elimination of self-reactive T cells …

Colorectal cancer (CRC) caused over 900,000 deaths worldwide in 2020. A majority of late-
stage CRC patients are treated with 5-fluorouracil (5-FU) combined with either irinotecan …