LNCcation: lncRNA localization and function

MC Bridges, AC Daulagala, A Kourtidis - Journal of Cell Biology, 2021 - rupress.org
Subcellular localization of RNAs has gained attention in recent years as a prevalent
phenomenon that influences numerous cellular processes. This is also evident for the large …

Alternative polyadenylation of mRNA precursors

B Tian, JL Manley - Nature reviews Molecular cell biology, 2017 - nature.com
Alternative polyadenylation (APA) is an RNA-processing mechanism that generates distinct
3′ termini on mRNAs and other RNA polymerase II transcripts. It is widespread across all …

Unique features of long non-coding RNA biogenesis and function

JJ Quinn, HY Chang - Nature reviews genetics, 2016 - nature.com
Long non-coding RNAs (lncRNAs) are a diverse class of RNAs that engage in numerous
biological processes across every branch of life. Although initially discovered as mRNA-like …

Potential of long non‐coding RNAs in cancer patients: from biomarkers to therapeutic targets

S Chandra Gupta… - International journal of …, 2017 - Wiley Online Library
Because of high specificity and easy detection in the tissues, serum, plasma, urine and
saliva, interest in exploring the potential of long non‐coding RNAs (lncRNAs) in cancer …

[HTML][HTML] Genome-wide quantification of RNA flow across subcellular compartments reveals determinants of the mammalian transcript life cycle

R Ietswaart, BM Smalec, A Xu, K Choquet, E McShane… - Molecular Cell, 2024 - cell.com
Dissecting the regulatory mechanisms controlling mammalian transcripts from production to
degradation requires quantitative measurements of mRNA flow across the cell. We …

Long non-coding RNAs are emerging targets of phytochemicals for cancer and other chronic diseases

S Mishra, SS Verma, V Rai, N Awasthee… - Cellular and Molecular …, 2019 - Springer
The long non-coding RNAs (lncRNAs) are the crucial regulators of human chronic diseases.
Therefore, approaches such as antisense oligonucleotides, RNAi technology, and small …

CRISPR/Cas9‐mediated mutagenesis of lncRNA1459 alters tomato fruit ripening

R Li, D Fu, B Zhu, Y Luo, H Zhu - The Plant Journal, 2018 - Wiley Online Library
With the development of high‐throughput sequencing, many long non‐coding RNA s (lnc
RNA s) have been found to play important roles in diverse biological processes. However …

Identification of the long non-coding RNA H19 in plasma as a novel biomarker for diagnosis of gastric cancer

X Zhou, C Yin, Y Dang, F Ye, G Zhang - Scientific reports, 2015 - nature.com
Recent studies have demonstrated that long non-coding RNAs (lncRNAs) are regarded as
useful tools for cancer detection, particularly for the early stage; however, little is known …

Identification of a nuclear exosome decay pathway for processed transcripts

N Meola, M Domanski, E Karadoulama, Y Chen… - Molecular cell, 2016 - cell.com
The RNA exosome is fundamental for the degradation of RNA in eukaryotic nuclei. Substrate
targeting is facilitated by its co-factor Mtr4p/hMTR4, which links to RNA-binding protein …

Systematic profiling of poly (A)+ transcripts modulated by core 3'end processing and splicing factors reveals regulatory rules of alternative cleavage and …

W Li, B You, M Hoque, D Zheng, W Luo, Z Ji… - PLoS …, 2015 - journals.plos.org
Alternative cleavage and polyadenylation (APA) results in mRNA isoforms containing
different 3'untranslated regions (3'UTRs) and/or coding sequences. How core cleavage …