Proteostasis in aging-associated ocular disease
Vision impairment has devastating consequences for the quality of human life. The cells and
tissues associated with the visual process must function throughout one's life span and …
tissues associated with the visual process must function throughout one's life span and …
Newfound physiological function of FAIM protein offers hope of novel disease-modifying therapy for Alzheimer's disease
AR Balaj, H Kaku - Neural Regeneration Research, 2023 - journals.lww.com
(FAIM): FAIM was originally discovered in FAS-resistant mouse primary B lymphocytes in
1999, and was thought of as a FAS-apoptosis inhibitor based on overexpression studies …
1999, and was thought of as a FAS-apoptosis inhibitor based on overexpression studies …
The absence of FAIM leads to a delay in dark adaptation and hampers arrestin-1 translocation upon light reception in the retina
A Sirés, M Pazo-González, J López-Soriano, A Méndez… - Cells, 2023 - mdpi.com
The short and long isoforms of FAIM (FAIM-S and FAIM-L) hold important functions in the
central nervous system, and their expression levels are specifically enriched in the retina …
central nervous system, and their expression levels are specifically enriched in the retina …
FAIM Enhances the Efficacy of Mesenchymal Stem Cell Transplantation by Inhibiting JNK‐Induced c‐FLIP Ubiquitination and Degradation
J Chen, F Liu, W Hu, Y Qian, D Xu, C Gao… - Stem Cells …, 2022 - Wiley Online Library
Background. The poor survival rates of transplanted mesenchymal stem cells (MSCs) in
harsh microenvironments impair the efficacy of MSCs transplantation in myocardial …
harsh microenvironments impair the efficacy of MSCs transplantation in myocardial …
FAIM-L-SIVA-1: Two Modulators of XIAP in Non-Apoptotic Caspase Function
E Coccia, M Solé, JX Comella - Frontiers in cell and developmental …, 2022 - frontiersin.org
Apoptosis is crucial for the correct development of the nervous system. In adulthood, the
same protein machinery involved in programmed cell death can control neuronal …
same protein machinery involved in programmed cell death can control neuronal …
[PDF][PDF] FAIM-L participation in Alzheimer's Disease and other tauopathies: Deciphering the role of FAIM-L in tau ubiquitination, synaptic maintenance, and memory …
R Badillos Rodríguez - 2023 - ddd.uab.cat
Alzheimer's disease (AD) is the most prevalent type of dementia worldwide and one of the
most relevant disorders among a group of neurodegenerative diseases named tauopathies …
most relevant disorders among a group of neurodegenerative diseases named tauopathies …
Unveiling the role of FAIM in the retina: Characterization of the neurodegenerative and functional alterations of a FAIM knockout mouse model and associated …
A Martinez Sires - 2022 - ddd.uab.cat
Fas Apoptotic Inhibitory Molecule protein (FAIM) was first described as a death-receptor
antagonist and an apoptosis regulator. However, new roles like ubiquitin modulation and …
antagonist and an apoptosis regulator. However, new roles like ubiquitin modulation and …