Alternative to FBS in animal cell culture-An overview and future perspective

KS Chelladurai, JDS Christyraj, K Rajagopalan… - Heliyon, 2021 - cell.com
Fetal bovine serum (FBS) is a widely used growth supplement in the in vitro culturing of
animal and human cells, tissues and organs, notably due to the occurrence of abundant …

Human milk oligosaccharides: every baby needs a sugar mama

L Bode - Glycobiology, 2012 - academic.oup.com
Human milk oligosaccharides (HMOs) are a family of structurally diverse unconjugated
glycans that are highly abundant in and unique to human milk. Originally, HMOs were …

Sialic acids in cancer biology and immunity

OMT Pearce, H Läubli - Glycobiology, 2016 - academic.oup.com
During malignant transformation, glycosylation is heavily altered compared with healthy
tissue due to differential expression of glycosyltransferases, glycosidases and …

A red meat-derived glycan promotes inflammation and cancer progression

AN Samraj, OMT Pearce, H Läubli… - Proceedings of the …, 2015 - National Acad Sciences
A well known, epidemiologically reproducible risk factor for human carcinomas is the long-
term consumption of “red meat” of mammalian origin. Although multiple theories have …

Multifarious roles of sialic acids in immunity

A Varki, P Gagneux - Annals of the New York Academy of …, 2012 - Wiley Online Library
Sialic acids are a diverse family of monosaccharides widely expressed on all cell surfaces of
vertebrates and so‐called “higher” invertebrates, and on certain bacteria that interact with …

Production platforms for biotherapeutic glycoproteins. Occurrence, impact, and challenges of non-human sialylation

D Ghaderi, M Zhang, N Hurtado-Ziola… - Biotechnology and …, 2012 - Taylor & Francis
One of the fastest growing fields in the pharmaceutical industry is the market for therapeutic
glycoproteins. Today, these molecules play a major role in the treatment of various diseases …

Implications of the presence of N-glycolylneuraminic acid in recombinant therapeutic glycoproteins

D Ghaderi, RE Taylor, V Padler-Karavani, S Diaz… - Nature …, 2010 - nature.com
Recombinant glycoprotein therapeutics produced in nonhuman mammalian cell lines and/or
with animal serum are often modified with the nonhuman sialic acid N-glycolylneuraminic …

Sialic acid metabolism and sialyltransferases: natural functions and applications

Y Li, X Chen - Applied microbiology and biotechnology, 2012 - Springer
Sialic acids are a family of negatively charged monosaccharides which are commonly
presented as the terminal residues in glycans of the glycoconjugates on eukaryotic cell …

Involvement of a non-human sialic acid in human cancer

AN Samraj, H Läubli, N Varki, A Varki - Frontiers in oncology, 2014 - frontiersin.org
Sialic acids are common monosaccharides that are widely expressed as outer terminal units
on all vertebrate cell surfaces, and play fundamental roles in cell–cell and cell …

Sugar‐coated sperm: unraveling the functions of the mammalian sperm glycocalyx

E Tecle, P Gagneux - Molecular reproduction and development, 2015 - Wiley Online Library
Mammalian spermatozoa are coated with a thick glycocalyx that is assembled during sperm
development, maturation, and upon contact with seminal fluid. The sperm glycocalyx is …