Mesenchymal Stem Cell-Derived Extracellular Vesicles in Bone-Related Diseases: Intercellular Communication Messengers and Therapeutic Engineering …

Y Wang, J Wen, T Lu, W Han, K Jiao… - International Journal of …, 2024 - Taylor & Francis
Extracellular vesicles (EVs) can deliver various bioactive molecules among cells, making
them promising diagnostic and therapeutic alternatives in diseases. Mesenchymal stem cell …

Nerve Regeneration Potential of Antioxidant-Modified Black Phosphorus Quantum Dots in Peripheral Nerve Injury

J Shen, Y Sun, X Liu, Y Chai, C Wang, J Xu - ACS nano, 2024 - ACS Publications
Peripheral nerve injury is a major societal concern. Black phosphorus (BP) has inherent
advantages over cell-based therapies in regenerative medicine. However, controlling …

Inhibition of inflammatory osteoclasts accelerates callus remodeling in osteoporotic fractures by enhancing CGRP+TrkA+ signaling

Y Shu, Z Tan, Z Pan, Y Chen, J Wang, J He… - Cell Death & …, 2024 - nature.com
Impaired callus remodeling significantly contributes to the delayed healing of osteoporotic
fractures; however, the underlying mechanisms remain unclear. Sensory neuronal signaling …

M2 macrophage-derived cathepsin S promotes peripheral nerve regeneration via fibroblast–Schwann cell-signaling relay

E Oshima, Y Hayashi, Z Xie, H Sato, S Hitomi… - Journal of …, 2023 - Springer
Background Although peripheral nerves have an intrinsic self-repair capacity following
damage, functional recovery is limited in patients. It is a well-established fact that …

Cancer-mediated axonal guidance of sensory neurons in a microelectrode-based innervation MPS

M van der Moolen, A Lovera, F Ersoy, S Mommo… - …, 2024 - iopscience.iop.org
Despite recent advances in the field of microphysiological systems (MPSs), availability of
models capable of mimicking the interactions between the nervous system and innervated …

[HTML][HTML] Keratinocyte-derived extracellular vesicles in painful diabetic neuropathy

J Coy-Dibley, ND Jayaraj, D Ren, P Pacifico… - Neurobiology of Pain, 2025 - Elsevier
Painful diabetic neuropathy (PDN) is a challenging complication of diabetes with patients
experiencing a painful and burning sensation in their extremities. Existing treatments …

Myeloid zinc finger 1 knockdown promotes osteoclastogenesis and bone loss in part by regulating RANKL-induced ferroptosis of osteoclasts through Nrf2/GPX4 …

Z Qu, B Zhang, L Kong, Y Zhang, Y Zhao… - Journal of Leukocyte …, 2024 - academic.oup.com
The overactivation of the osteoclasts is a crucial pathological factor in the development of
osteoporosis. MZF1, belonging to the scan-zinc finger family, plays a significant role in …

神经血管耦合在骨修复中作用的研究进展

何姝航, 郭尚春, 陶诗聪 - 上海交通大学学报(医学版), 2024 - xuebao.shsmu.edu.cn
骨修复是一个复杂的生理过程, 骨内的神经通过释放生物活性分子以及与骨内细胞相互作用等
方式调节骨组织再生. 近年来, 已经有研究尝试基于神经血管耦合进行生物材料设计 …

Secretory factors released from high dose radiation-activated osteoclasts increase the expression level of pain-associated neuropeptides in sensory neuronal cultures

SH Park, M Peters, C Aguayo, MK Farris… - Research …, 2024 - pmc.ncbi.nlm.nih.gov
Stereotactic Body Radiation Therapy for lung tumors near the chest wall often causes
significant chest wall pain (CWP), negatively impacting patients' quality of life. The …

Inhibition of Inflammatory Osteoclasts Enhances CGRP+TrkA+ Signaling and Accelerates Callus Remodeling in Osteoporotic Fractures

Y Shu, Z Tan, Z Pan, Y Chen, J Wang, J He, J Wang… - bioRxiv, 2024 - biorxiv.org
Impaired callus remodeling significantly contributes to the delayed healing of osteoporotic
fractures; however, the underlying mechanisms remain unclear. Sensory neuronal signaling …