The multifunctional membrane glycoprotein CD36 is expressed in different types of cells and
plays a key regulatory role in cellular lipid metabolism, especially in cardiac muscle. CD36 …

THE definition of cellular organelles has evolved over the last hundred years largely driven
by morphologic observations, but more recently has been supplemented and complemented …

▪ Abstract Endocytosis in eukaryotic cells is characterized by the continuous and regulated
formation of prolific numbers of membrane vesicles at the plasma membrane. These …

Recent advances have uncovered the general protein apparatus used by all eukaryotes for
intracellular transport, including secretion and endocytosis, and for triggered exocytosis of …

THE fungal metabolite brefeldin A is a powerful tool for investigating membrane traffic in
eukaryotic cells1. The effects of brefeldin A on traffic are partly explained by its ability to …

Addition of brefeidin A (BFA) to most ceils results in both the formation of extensive,
uncoated membrane tubules through which Golgi components redistribute into the ER and …

▪ Abstract Green fluorescent protein chimerae acting as reporters for protein localization and
trafficking within the secretory membrane system of living cells have been used in a wide …

GOLGI-derived coated vesicles contain a set of coat proteins of relative molecular mass
160,000 (M r 160K; α-COP), 110K (β-COP), 98K (γ-COP) and 61K (δ-COP), and several …

The mechanism by which Golgi membrane proteins are retained within the Golgi complex in
the midst of a continuous flow of protein and lipid is not yet understood. The diffusional …

Exocytic transport from the endoplasmic reticulum (ER) to the Golgi complex has been
visualized in living cells using a chimera of the temperature-sensitive glycoprotein of …