From the molecular level up to a blood vessel, thrombosis and hemostasis involves many
interconnected biochemical and biophysical processes over a wide range of length and time …

Point-of-care diagnostics of platelet and coagulation function present demanding
challenges. Current clinical diagnostics often use centrifuged plasmas or platelets and …

Shear-induced platelet aggregation (SIPA) occurs under elevated shear rates (10 000 s− 1)
found in stenotic coronary and carotid arteries. The pathologically high shear environment …

Coronary artery thrombosis is the major risk associated with Kawasaki disease (KD). Long-
term management of KD patients with persistent aneurysms requires a thrombotic risk …

Platelet adhesion and activation are essential initial processes of arterial and microvascular
hemostasis, where high hydrodynamic forces from the bloodflow impede coagulation. The …

A multimeric glycoprotein of blood plasma—Von Willebrand factor (VWF)—mediates platelet
adhesion to the fibrillar collagen of the subendothelial matrix if the blood vessel walls are …

Abstract von Willebrand Factor is a mechano-sensitive protein circulating in blood that
mediates platelet adhesion to subendothelial collagen and platelet aggregation at high …

An ongoing thrombosis on a ruptured atherosclerotic plaque in the carotid may cause stroke.
The primary treatment for patients with tandem lesion is stenting. Dual-layer stents have …

An excessive von Willebrand factor (VWF) secretion, coupled with a moderate to severe
deficiency of ADAMTS13 activity, serves as a linking mechanism between inflammation to …

Platelet aggregation is a dynamic process that can obstruct blood flow, leading to
cardiovascular diseases. While many studies have demonstrated clear connections …