Glioblastoma (GBM) is a highly malignant brain tumor characterized by a heterogeneous
population of genetically unstable and highly infiltrative cells that are resistant to …

CHRFAM7A is a relatively recent and exclusively human gene arising from the partial
duplication of exons 5 to 10 of the α7 neuronal nicotinic acetylcholine receptor subunit (α7 …

Within the superfamily of pentameric ligand-gated ion channels, cholinergic nicotinic
receptors (nAChRs) were classically identified to mediate synaptic transmission in the …

The pentameric nicotinic acetylcholine receptors (nAChRs) are typically classed as muscle-
or neuronal-type, however, the latter has also been reported in non-neuronal cells. Given …

Nicotinic acetylcholine receptors (nAChRs) are pentameric ligand-gated ion channels
involved in the modulation of essential brain functions such as memory, learning, and …

Nicotine in tobacco is known to induce tumor-promoting effects and cause chemotherapy
resistance through the activation of nicotinic acetylcholine receptors (nAChRs). Many …

Introduction There is a lack of robust metabolic imaging techniques that can be routinely
applied to characterize lesions in patients with brain tumors. Here we explore in an animal …

Neuronal nicotinic acetylcholine receptors containing the α9 or the α9 and α10 subunits are
expressed in various extra-neuronal tissues. Moreover, most cancer cells and tissues highly …

Glioma is the most common intracranial malignant tumor, with severe difficulty in treatment
and a low patient survival rate. Due to the heterogeneity and invasiveness of tumors, lack of …

Glioblastoma (GBM) is a highly aggressive and lethal brain tumor with limited treatment
options, such as the chemotherapeutic agent, temozolomide (TMZ). However, many GBM …