Epidemiological studies showed that the metabolic syndromes (MetS) and cardiovascular
diseases (CVDs) are responsible for a serious threat to human health worldwide. MetS is a …

Abstract Ethnopharmacological relevance Panax notoginseng (Burk.) FH Chen is a widely
used traditional Chinese medicine known as Sanqi or Tianqi in China. This plant, which is …

Previous studies show that notoginsenoside R1 (NG-R1), a novel saponin isolated from
Panax notoginseng, protects kidney, intestine, lung, brain and heart from ischemia …

Acute lung injury (ALI), a severe and life-threatening inflammation of the lung, with high
morbidity and mortality, underscoring the urgent need for novel treatments. Ge-Gen-Qin-Lian …

As plant-derived natural products, saponins have been widely applied for the dietary
modification of metabolic syndrome. However, the underlying mechanisms of their …

Coronary artery disease (CAD) is a major public health problem and the chief cause of
morbidity and mortality worldwide. Panax notoginseng, a valuable herb in traditional …

Diabetic nephropathy (DN) is a leading cause of end-stage renal failure, and no effective
treatment is available. Notoginsenoside R1 (NGR1) is a novel saponin that is derived from …

Rationale: The renin-angiotensin system is a complex regulatory network that maintains
normal physiological functions. The role of the renin-angiotensin system in sepsis-induced …

Therapeutic agents used to treat sepsis‑induced cardiac dysfunction are designed to
suppress tumor necrosis factor (TNF)‑α release and inhibit cell apoptosis. Exogenous …

Myocardial dysfunction is an important manifestation of sepsis. Previous studies suggest that
melatonin is protective against sepsis. In addition, activation of the phosphatidylinositol 3 …