In two landmark articles, Hanahan and Weinberg synthesized into one conceptual
framework 'the hallmarks of cancer', a massive amount of information describing the …

Understanding of dedifferentiation, an indicator of poo prognosis for patients with thyroid
cancer, has been hampered by imprecise and incomplete characterization of its …

The cancer stem cells (CSC) hypothesis represents a pathological extrapolation of the
physiological concept of embryonic and somatic stem cells. In its initial definition, it …

Background Pediatric inflammatory bowel disease (IBD) is challenging to diagnose because
of the non-specificity of symptoms; an unequivocal diagnosis can only be made using …

Background The L-type amino acid transporter 1 (LAT1/SLC7A5) transports essential amino
acids across the plasma membrane. While LAT1 is overexpressed in a variety of human …

Thyroid hormone receptor α1 (TRα1) mediates the genomic actions of thyroid hormone (T3).
The biology of TRα1 in growth and development has been well studied, but the functional …

Background 'Stable disease (SD)'as per RECIST is a common but ambiguous outcome in
patients receiving immune checkpoint inhibitors (ICIs). This study aimed to characterize SD …

Aberrant lipid metabolism provides bioenergetic, biosynthetic, and redox supplies to cancer
cells. Previous studies have reported differential lipid profiling in thyroid malignancies. Sterol …

Background and Objectives Targeting cancer-associated fibroblast (CAF) is being explored
as an approach to improve cancer therapies. The roles of CAF remain unclarified in …

Background Thyroid carcinoma includes several variants characterized by different
biological and clinical features: from indolent microcarcinoma to undifferentiated and …