At present, the idea of genome modification has revolutionized the modern therapeutic
research era. Genome modification studies have traveled a long way from gene …

Drosophila has long been a premier model for the development and application of cutting-
edge genetic approaches. The CRISPR-Cas system now adds the ability to manipulate the …

Biomolecular condensates organize biochemical processes at the subcellular level and can
provide spatiotemporal regulation within a cell. Among these, ribonucleoprotein (RNP) …

Advances in CRISPR technology have immensely improved our ability to manipulate nucleic
acids, and the recent discovery of the RNA-targeting endonuclease Cas13 adds even further …

The rise of a pest species represents a unique opportunity to address how species evolve
new behaviors and adapt to novel ecological niches [1]. We address this question by …

Embryonic cell fates are defined by transcription factors that are rapidly deployed, yet
attempts to visualize these factors in vivo often fail because of slow fluorescent protein …

For more than 100 years, the fruit fly, Drosophila melanogaster, has served as a powerful
model organism for biological and biomedical research due to its many genetic and …

In developing brains, axons exhibit remarkable precision in selecting synaptic partners
among many non-partner cells. Evolutionarily conserved teneurins are transmembrane …

Neurexins are key adhesion proteins that coordinate extracellular and intracellular synaptic
components. Nonetheless, the low abundance of these multidomain proteins has …

Cilia are cellular projections that perform sensory and motile functions in eukaryotic cells. A
defining feature of cilia is that they are evolutionarily ancient, yet not universally conserved …