Simple Summary There are three subfamilies of human PDZ-LIM family proteins with a total
of 10 protein molecules, and PDZ-LIM family proteins serve as a class of scaffolding proteins …

Significant reprogramming of epigenome is widely described during pathogenesis of breast
cancer. Transformation of normal cell to hyperplastic cell and to neoplastic phenotype is …

Epigenetic changes are considered to be a frequent event during tumour development.
Hypermethylation of promoter CpG islands represents an alternative mechanism to …

Background: Breast (BrC), colorectal (CRC) and lung (LC) cancers are the three most
common and deadly cancers in women. Cancer screening entails an increase in early stage …

Breast cancer is the most commonly diagnosed cancer in women and the second most
common cause of cancer-related deaths in the United States. Although early detection has …

Background Cancer-associated fibroblasts (CAFs) contribute to the progression and
treatment of breast cancer (BRCA); however, risk signatures and molecular targets based on …

Clinical management of breast cancer is increasingly personalized and based on molecular
profiling. Often, primary tumors are used as proxies for systemic disease at the time of …

Background We previously reported increased risk of breast cancer associated with early life
exposure to two measures of air pollution exposure, total suspended particulates (TSP) and …

Background Invasion and metastasis are two important hallmarks of malignant tumors
caused by complex genetic and epigenetic alterations. The present study investigated the …

Breast cancer is the most common cancer in women worldwide, representing 28.2% of all
female malignancies. In addition to genetic changes, epigenetic events, as aberrant DNA …