Many active pharmaceutical ingredients (APIs) exhibit poor solubility and low dissolution
rates in aqueous environments such as the luminal fluids of the gastrointestinal tract. The …

Buccal mucosal membrane offers an attractive drug-delivery route to enhance both systemic
and local therapy. This review discusses the benefits and drawbacks of buccal drug delivery …

Owing to the ease of the administration, the oral cavity is an attractive site for the delivery of
drugs. Through this route it is possible to realize mucosal (local effect) and transmucosal …

Supramolecular systems formed by the binding of several cyclodextrins (CDs) to polymers or
lipids, either via non-covalent or covalent links, open a wide range of possibilities for the …

Highlights•Cyclodextrins are complexing excipients in tablets mainly for potent
drugs.•Methods to enhance the complexation efficiency decrease the cyclodextrin …

Background: Cyclodextrins (CDs) are versatile excipients with an essential role in drug
delivery, as they can form non-covalently bonded inclusion complexes (host-guest …

Felodipine (FDP), a dihydropyridine calcium-channel antagonist is used for the treatment of
hypertension and angina pectoris. FDP is poorly soluble drug and upon oral administration …

Creating in situ phase separation in solid dispersion based formulations to allow enhanced
functionality of the dosage form, such as improving dissolution of poorly soluble model drug …

Over the last decade, there has been a particular interest in delivering drugs in buccal
mucosa and aiming to increase bioavailability of varied controlled drug delivery systems …

The objective of this research was to investigate physicochemical properties of an active
pharmaceutical ingredient (API) that influence cyclodextrin complexation through …