Metabolites produced by commensal gut microbes impact host health through their
recognition by the immune system and their influence on numerous metabolic pathways …

Metabolic abnormalities lead to the dysfunction of metabolic pathways and metabolite
accumulation or deficiency which is well-recognized hallmarks of diseases. Metabolite …

The human gastrointestinal tract is populated with a diverse microbial community. The vast
genetic and metabolic potential of the gut microbiome underpins its ubiquity in nearly every …

The gut microbiota, housing trillions of microorganisms within the gastrointestinal tract, has
emerged as a critical regulator of host health and homeostasis. Through complex metabolic …

Accumulating evidence suggests that cardiovascular disease (CVD) is associated with an
altered gut microbiome. Our understanding of the underlying mechanisms has been …

Cardiometabolic disease comprises cardiovascular and metabolic dysfunction and
underlies the leading causes of morbidity and mortality, both within the United States and …

Propionate is a short-chain fatty acid that is generated upon microbiome-mediated fiber
fermentation in the intestine. By modulating immune and metabolic pathways, propionate …

Aspirin-related gastrointestinal damage is of growing concern. Aspirin use modulates the gut
microbiota and associated metabolites, such as bile acids (BAs), but how this impacts …

The intestinal microbiota composition and associated bioactivities are sensitive to various
modifier cues such as stress, inflammation, age, life-style and nutrition, which in turn are …

Bile acids regulate nutrient absorption and mitochondrial function, they establish and
maintain gut microbial community composition and mediate inflammation, and they serve as …