Heparin, a sulfated polysaccharide belonging to the family of glycosaminoglycans, has
numerous important biological activities, associated with its interaction with diverse proteins …

Publisher Summary This chapter discusses the structural aspects and structure–activity
relationships of heparin/heparan sulfate (HS). The molecular mechanism behind the …

The endoglycosidase heparanase is an important in the degradation of the extracellular
matrix by invading cells, notably metastatic tumor cells and migrating leukocytes. Here we …

It is widely accepted that tissue differentiation and morphogenesis in multicellular organisms
are regulated by tightly controlled concentration gradients of morphogens,. How exactly …

A vascular endothelial growth factor (VEGF) mRNA species containing exons 1-6 and 8 of
the VEGF gene was found to be expressed as a major VEGF mRNA form in several cell lines …

Glycosarninoglycans (GAGs) play an intricate role in the extracellular matrix (ECM), not only
as soluble components and polyelectrolytes, but also by specific interactions with growth …

Extracellular modulation of phenotype is an emerging paradigm in this current postgenomics
age of molecular and cell biology. Glycosaminoglycans (GAGs) are primary components of …

Heparan sulfate, a highly sulfated polysaccharide, is present on the surface of mammalian
cells and in the extracellular matrix in large quantities. The sulfated monosaccharide …

Humans express seven heparan sulfate (HS) 3-O-sulfotransferases that differ in substrate
specificity and tissue expression. Although genetic studies have indicated that 3-O-sulfated …

Heparin and heparan sulfates are closely related linear anionic polysaccharides, called
glycosaminoglycans, which exhibit a number of important biological and pharmacological …