The importance of transcriptomics and proteomics for studying molecular mechanisms of mycotoxin exposure: A review

A Cimbalo, M Frangiamone, G Font… - Food and Chemical …, 2022 - Elsevier
This review aims to highlight recent advances where transcriptomics and proteomics have
been used as a key tool to understand molecular toxicity of mycotoxins. The most studied …

From ribosome to ribotoxins: Understanding the toxicity of deoxynivalenol and Shiga toxin, two food borne toxins

M Garofalo, D Payros, F Taieb, E Oswald… - Critical Reviews in …, 2025 - Taylor & Francis
Ribosomes that synthesize proteins are among the most central and evolutionarily
conserved organelles. Given the key role of proteins in cellular functions, prokaryotic and …

[HTML][HTML] Deoxynivalenol triggers porcine intestinal tight junction disorder: Insights from mitochondrial dynamics and mitophagy

C Zhang, KF Zhang, FJ Chen, YH Chen, X Yang… - Ecotoxicology and …, 2022 - Elsevier
Deoxynivalenol (DON) is universally detected trichothecene in most cereal commodities,
which is considered as a major hazardous material for human and animal health. Intestine is …

[HTML][HTML] Dietary taurine supplementation counteracts deoxynivalenol-induced liver injury via alleviating oxidative stress, mitochondrial dysfunction, apoptosis, and …

X Ji, Z Tang, F Zhang, F Zhou, Y Wu, D Wu - … and Environmental Safety, 2023 - Elsevier
Deoxynivalenol (DON), as a widespread Fusarium mycotoxin in cereals, food products, and
animal feed, is detrimental to both human and animal health. The liver is not only the primary …

Resveratrol protects against deoxynivalenol-induced ferroptosis in HepG2 cells

P Wang, Q Yao, D Zhu, X Yang, Q Chen, Q Lu, A Liu - Toxicology, 2023 - Elsevier
Deoxynivalenol (DON) is one of the most serious mycotoxins that contaminate food and
feed, causing hepatocyte death. However, there is still a lack of understanding regarding the …

Selenomethionine protects the liver from dietary deoxynivalenol exposure via Nrf2/PPARγ-GPX4-ferroptosis pathway in mice

S Fan, L Lin, P Li, H Tian, J Shen, L Zhou, Q Zhao… - Toxicology, 2024 - Elsevier
Deoxynivalenol (DON) is a significant Fusarium toxin that has gained global attention due to
its high frequency of contamination in food and feed. It was reported to have hepatotoxicity …

Toxicity of the emerging mycotoxins beauvericin and enniatins: A mini-review

AL Hasuda, APFRL Bracarense - Toxicon, 2024 - Elsevier
Beauvericin and enniatins, emerging mycotoxins produced mainly by Fusarium species, are
natural contaminants of cereals and cereal products. These mycotoxins are cyclic …

CYP2E1 mediated deoxynivalenol-induced hepatocyte toxicity by regulating ferroptosis

Q Mo, C Song, Y Hua, W Wang, A Liu - Toxicology, 2024 - Elsevier
Deoxynivalenol (DON), one of the most common mycotoxins in food and feed, can cause
acute and chronic liver injury, posing a serious health risk to humans and animals. One of …

An integrated mycotoxin-mitigating agent can effectively mitigate the combined toxicity of AFB1, DON and OTA on the production performance, liver and oviduct health …

ML Ruan, J Wang, ZY Xia, XW Li, B Zhang… - Food and Chemical …, 2023 - Elsevier
This study was to evaluate the efficacy of an integrated mycotoxin-mitigating agent in
reducing the adverse effects of co-occurring dietary aflatoxin B 1 deoxynivalenol and …

Effects of continuous LPS induction on oxidative stress and liver injury in weaned piglets

Y Zhou, X Hu, S Zhong, W Yu, J Wang, W Zhu… - Veterinary …, 2022 - mdpi.com
Simple Summary Pigs have been evaluated as good model animals for human
physiological and pathological research. During the weaned period, piglets are vulnerable …