Glioblastoma multiform (GBM) is the most common malignant glioma of all the brain tumors
and currently effective treatment options are still lacking. GBM is frequently accompanied …

Malignant astrocytic gliomas such as glioblastoma are the most common and lethal
intracranial tumors. These cancers exhibit a relentless malignant progression characterized …

Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL), also known as Apo-
2 ligand (Apo2L), is a member of the TNF cytokine superfamily. By cross-linking TRAIL …

Both pro-and antioncogenic properties have been attributed to EphA2 kinase. We report that
a possible cause for this apparent paradox is diametrically opposite roles of EphA2 in …

Gliomas are the most common and challenging malignancies of the central nervous system
(CNS), due to their infiltrative nature, tendency to recurrence, and poor response to …

Gliomas are the most common intracranial tumors. In the US, approximately 15,000 patients
die with glioblastoma per year (CBTRUS 2002). Despite modern diagnostics and treatments …

Purpose The present review aims to emphasize that malignant gliomas are characterized by
the diffuse invasion of distant brain tissue by a myriad of single migrating cells that exhibit …

The invasive phenotype of glioblastoma multiforme (GBM) is a hallmark of malignant
process, yet molecular mechanisms that dictate this locally invasive behavior remain poorly …

Learning Objectives After completing this course, the reader will be able to: Describe the
pathways involved in the natural resistance of cancer cells to cytotoxic insults including radio …

The aggressive and rapidly lethal brain tumor glioblastoma (GBM) is associated with
profound tissue stiffening and genomic lesions in key members of the epidermal growth …