The mammary gland is a compound, branched tubuloalveolar structure and a major
characteristic of mammals. The mammary gland has evolved from epidermal apocrine …

Single-cell manipulation and analysis is critical to the study of many fundamental biological
processes and uncovering cellular heterogeneity, and presents the potential for extremely …

Our understanding of the molecular events underpinning the development of mammalian
organ systems has been increasing rapidly in recent years. With the advent of new and …

Metaplastic breast carcinoma (MBC) is a highly aggressive form of triple-negative cancer
(TNBC), defined by the presence of metaplastic components of spindle, squamous, or …

The mammary gland (MG) is an exocrine gland present in female mammals responsible for
the production and secretion of milk during the process of lactation. It is mainly composed by …

Maintenance of undifferentiated, long-lived, and often quiescent stem cells in the basal
compartment is important for homeostasis and regeneration of multiple epithelial tissues, but …

Cells in human milk are an untapped source, as potential “liquid breast biopsies”, of material
for investigating lactation physiology in a non-invasive manner. We used single cell RNA …

The mammary gland is unique in female mammals. Mammary tissue undergoes
development and remodeling during lactation, a stage associated with high susceptibility to …

Background Studying the composition and developmental mechanisms in mammary gland
is crucial for healthy growth of newborns. The mammary gland is inherently heterogeneous …

Cancer prevention has a profound impact on cancer-associated mortality and morbidity. We
previously identified TGFβ signaling as a candidate regulator of mammary epithelial cells …