Our understanding of the molecular events underpinning the development of mammalian
organ systems has been increasing rapidly in recent years. With the advent of new and …

Organoid cultures offer a valuable platform for studying organ-level biology, allowing for a
closer mimicry of human physiology compared to traditional two-dimensional cell culture …

While mouse models and two-dimensional (2D) cell culture systems have dominated as
research tools for cancer biology, three-dimensional (3D) cultures have gained traction as a …

Rank signaling pathway regulates mammary gland homeostasis and epithelial cell
differentiation. Although Rank receptor is expressed by basal cells and luminal progenitors …

During the last decade, biomedical research has experienced a resurgence in the use of
three-dimensional culture models for studies of normal and cancer biology. This resurgence …

Pregnancy reprograms mammary epithelial cells (MECs) to control their responses to
pregnancy hormone re-exposure and carcinoma progression. However, the influence of …

The onset of pregnancy marks the start of offspring development, and represents the key
physiological event that induces re-organization and specialization of breast tissue. Such …

The use of mouse derived mammary organoids can provide a unique strategy to study
mammary gland development across a normal life cycle, as well as offering insights into how …

The developing mammary gland depends on several transcription-dependent networks to
define cellular identities and differentiation trajectories. Recent technological advancements …

Simple Summary Secreted Frizzled-Related Protein 1 (SFRP1) expression is decreased
during breast cancer progression and inversely associated with breast tissue age-related …