The consequences of cerebrovascular disease are among the leading health issues
worldwide. Large and small cerebral vessel disease can trigger stroke and contribute to the …

Current understanding on the mechanisms of brain injury and neurodegeneration highlights
an appreciation of multicellular interactions within the neurovascular unit (NVU), which …

Population aging that we are currently witnessing has led to an increase in chronic age-
related diseases, with dementia and depression being highlighted. Several studies establish …

Introduction Neuropathic pain is a debilitating condition. The importance of neuroimmune
interactions in neuropathic pain has been evidenced by the involvement of different immune …

Chronic pain is one of the most common, costly, and potentially debilitating health issues
facing older adults, with attributable costs exceeding $600 billion annually. The prevalence …

Microglia, the resident mononuclear phagocyte population in the brain, have long been
implicated in the pathology of neurodegenerative age-associated disorders. However …

Age-dependent alterations in microglia behavior have been implicated in
neurodegeneration and CNS injuries. Here, we compared the transcriptional profiles of …

In rodents, susceptibility to diet-induced obesity requires microglial activation, but the
molecular components of this pathway remain incompletely defined. Prostaglandin PGE2 …

The review summarizes data of recent experimental studies on spinal microglia, the least
explored cells of the spinal cord. It focuses on the origin and function of microglia in …

Objective Microgliosis, the activation of microglial cells, is thought to contribute to synaptic
transmission in the dorsal horn and thereby promote chronic pain. The primary aim of this …