Physical forces and mechanical properties have critical roles in cellular function, physiology
and disease. Over the past decade, atomic force microscopy (AFM) techniques have …

One of the most striking adaptations to exercise is the skeletal muscle hypertrophy that
occurs in response to resistance exercise. A large body of work shows that a mammalian …

The thick filament is a key component of sarcomeres, the basic units of striated muscle.
Alterations in thick filament proteins are associated with familial hypertrophic …

Mechanochemistry refers to unusual chemical reactions induced by mechanical energy at
room temperatures. It has attracted increased attention because of advantages, such as …

Although the shapes of organisms are encoded in their genome, the developmental
processes that lead to the final form of vertebrates involve a constant feedback between …

NBR1 was discovered as an autophagy receptor not long after the first described vertebrate
autophagy receptor p62/SQSTM1. Since then, p62 has currently been mentioned in> 10,000 …

Tissue development is orchestrated by the coordinated activities of both chemical and
physical regulators. While much attention has been given to the role that chemical regulators …

Mammalian skeletal muscle comprises different fiber types, whose identity is first established
during embryonic development by intrinsic myogenic control mechanisms and is later …

The recent discovery of heterozygous human mutations that truncate full-length titin (TTN, an
abundant structural, sensory, and signaling filament in muscle) as a common cause of end …

Critical illness polyneuropathies (CIP) and myopathies (CIM) are common complications of
critical illness. Several weakness syndromes are summarized under the term intensive care …