Bone is a dynamic organ maintained by tightly regulated mechanisms. With old age, bone
homeostasis, which is maintained by an intricate balance between bone formation and bone …

We discuss protein post‐translational modification (PTM) from an information processing
perspective. PTM at multiple sites on a protein creates a combinatorial explosion in the …

Post-translational modifications (PTMs) regulate many aspects of protein function and are
indispensable for the spatio-temporal regulation of cellular processes. The proteome-wide …

Poly (ADP-ribosyl) ation (PARylation) is catalysed by poly (ADP-ribose) polymerases
(PARPs, also known as ARTDs) and then rapidly removed by degrading enzymes. Poly …

Poly (ADP-ribose)(PAR) is a nucleic acid-like protein modification that can seed the
formation of microscopically visible cellular compartments that lack enveloping membranes …

Summary ARTD1 (PARP1) is a key enzyme involved in DNA repair through the synthesis of
poly (ADP-ribose)(PAR) in response to strand breaks, and it plays an important role in cell …

Simple Summary Poly (ADP-ribose) polymerase 1 (PARP1) is perhaps the most studied
member of the PARP superfamily and participates in numerous cellular processes. PARP1 …

Summary Poly (ADP-ribose)(PAR) is an RNA-like polymer that regulates an increasing
number of biological processes. Dysregulation of PAR is implicated in neurodegenerative …

Distinct properties of poly (ADP-ribose)—including its structural diversity, nucleation
potential, and low complexity, polyvalent, highly charged nature—could contribute to …

Abstract Poly (ADP-ribose)(PAR), a non-canonical nucleic acid, is essential for DNA/RNA
metabolism and protein condensation, and its dysregulation is linked to cancer and …