Drug delivery to the posterior segment of the eye: biopharmaceutic and pharmacokinetic considerations

R Varela-Fernández, V Díaz-Tomé… - Pharmaceutics, 2020 - mdpi.com
The treatment of the posterior-segment ocular diseases, such as age-related eye diseases
(AMD) or diabetic retinopathy (DR), present a challenge for ophthalmologists due to the …

Brolucizumab: a newly developed anti-VEGF molecule for the treatment of neovascular age-related macular degeneration

R Tadayoni, L Sararols, G Weissgerber, R Verma… - …, 2021 - karger.com
Background: Despite the success of anti-vascular endothelial growth factors (anti-VEGFs),
currently, there is a need for highly effective compounds that can alleviate the burden of …

Current and future anti-VEGF agents for neovascular age-related macular degeneration

SM Kaiser, S Arepalli, JP Ehlers - Journal of Experimental …, 2021 - Taylor & Francis
Age-related macular degeneration (AMD) is the most common cause of legal blindness in
developed countries. Neovascular (ie, wet) AMD is currently managed with intravitreal …

Thrombospondin-1 proteomimetic polymers exhibit anti-angiogenic activity in a neovascular age-related macular degeneration mouse model

W Choi, AK Nensel, S Droho, MA Fattah… - Science …, 2023 - science.org
Neovascular age-related macular degeneration (nAMD) is the leading cause of blindness in
the developed world. Current therapy includes monthly intraocular injections of anti-VEGF …

Hyaluronic acid: Its versatile use in ocular drug delivery with a specific focus on hyaluronic acid-based polyelectrolyte complexes

S Casey-Power, R Ryan, G Behl, P McLoughlin… - Pharmaceutics, 2022 - mdpi.com
Extensive research is currently being conducted into novel ocular drug delivery systems
(ODDS) that are capable of surpassing the limitations associated with conventional …

Gene therapy intervention in neovascular eye disease: a recent update

FL Lin, PY Wang, YF Chuang, JH Wang, VHY Wong… - Molecular Therapy, 2020 - cell.com
Aberrant growth of blood vessels (neovascularization) is a key feature of severe eye
diseases that can cause legal blindness, including neovascular age-related macular …

Six-month sustained delivery of anti-VEGF from in-situ forming hydrogel in the suprachoroidal space

JH Jung, SS Kim, H Chung, A Hejri… - Journal of Controlled …, 2022 - Elsevier
Patients with wet age-related macular degeneration (AMD) require intravitreal injections of
bevacizumab (Bev) or other drugs, often on a monthly basis, which is a burden on the …

Vitreous humor: composition, characteristics and implication on intravitreal drug delivery

D Mishra, S Gade, K Glover, R Sheshala… - Current eye …, 2023 - Taylor & Francis
Purpose: Intravitreal administration of drug molecules is one of the most common routes for
treating posterior segment eye diseases. However, the properties of vitreous humour …

[HTML][HTML] Prospective, longitudinal pilot study: daily self-imaging with patient-operated home OCT in neovascular age-related macular degeneration

TDL Keenan, M Goldstein, D Goldenberg, D Zur… - Ophthalmology …, 2021 - Elsevier
Purpose To evaluate longitudinally the performance of the Notal Vision Home OCT (NVHO),
comprising a spectral-domain OCT device for patient self-imaging at home, telemedicine …

Immunogenicity with ranibizumab biosimilar SB11 (Byooviz) and reference product Lucentis and association with efficacy, safety, and pharmacokinetics: a post hoc …

NM Bressler, T Kim, I Oh, P Russo, MY Kim… - JAMA …, 2023 - jamanetwork.com
Importance SB11 and reference ranibizumab (RBZ) are monoclonal anti–vascular
endothelial growth factor (VEGF)–A antibodies approved for the treatment of neovascular …