The number and subunit composition of synaptic N-methyl-d-aspartate receptors (NMDARs)
are not static, but change in a cell-and synapse-specific manner during development and in …

The formation of synapses in the vertebrate central nervous system is a complex process
that occurs over a protracted period of development. Recent work has begun to unravel the …

Integrin adhesion complexes (IACs) are integrin-based plasma-membrane-associated
compartments where cells sense environmental cues. The physical mechanisms and …

The mammalian central nervous system (CNS) requires the proper formation of exquisitely
precise circuits to function correctly. These neuronal circuits are assembled during …

Among diverse factors regulating excitatory synaptic transmission, the abundance of
postsynaptic glutamate receptors figures prominently in molecular memory and learning …

Dendritic spines are small protrusions that cover the surface of dendrites and bear the
postsynaptic component of excitatory synapses. Having an enlarged head connected to the …

Neuronal morphology and number of synapses is not static, but can change in response to a
variety of factors, a process called synaptic plasticity. These structural and molecular …

Most excitatory synapses terminate on dendritic spines. Spines vary in size, and their
volumes are proportional to the area of the postsynaptic density (PSD) and synaptic …

The postsynaptic density (PSD) is a complex assembly of proteins associated with the
postsynaptic membrane that organizes neurotransmitter receptors, signaling pathways, and …

Neurons are among the largest and most complex cells in the body. Their immense size and
intricate geometry pose many unique cell-biological problems. How is dendritic architecture …