Amino acid metabolism is a critical regulator of the immune response, and its modulating
becomes a promising approach in various forms of immunotherapy. Insufficient …

Background Macrophages are heterogenous phagocytic cells with an important role in the
innate immunity. They are, also, significant contributors in the adaptive immune system …

Mitochondria are important regulators of macrophage polarisation. Here, we show that
arginase-2 (Arg2) is a microRNA-155 (miR-155) and interleukin-10 (IL-10) regulated protein …

Elevated blood ammonia (hyperammonemia) is believed to be a major contributor to the
neurological sequelae following severe liver disease. Ammonia is cleared via two main …

Different thresholds of Wnt signalling are thought to drive stem cell maintenance,
regeneration, differentiation and cancer. However, the principle that oncogenic Wnt …

Hepatic ischemia-reperfusion (IR) injury is dynamically regulated by intertwined superoxide
anion (O 2 radical dot−)-peroxynitrite (ONOO−) cascaded molecules. Arginase 1 involves in …

While extensive investigations have been devoted to the study of genetic pathways related
to fatty liver diseases, much less is known about epigenetic mechanisms underlying these …

Bile acids activate farnesoid X receptor (FXR) and G protein–coupled bile acid receptor‐1
(aka Takeda G protein–coupled receptor‐5 [TGR5]) to regulate bile acid metabolism and …

The urea cycle disorder argininemia is caused by a defective arginase 1 (ARG1) enzyme
resulting from mutations in the ARG1 gene. Patients generally develop hyperargininemia …

Abstract Arginase 1 (Arg1) is a ubiquitous enzyme belonging to the urea cycle that catalyzes
the conversion of l-arginine into l-ornithine and urea. In endothelial cells (ECs), Arg1 was …